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Shannon L. Risacher
Researcher at Indiana University
Publications - 8
Citations - 258
Shannon L. Risacher is an academic researcher from Indiana University. The author has contributed to research in topics: Cognition & Amyloid beta. The author has an hindex of 4, co-authored 8 publications receiving 121 citations. Previous affiliations of Shannon L. Risacher include University of Pennsylvania.
Papers
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Journal ArticleDOI
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.
Kwangsik Nho,Alexandra Kueider-Paisley,Siamak MahmoudianDehkordi,Matthias Arnold,Shannon L. Risacher,Gregory Louie,Colette Blach,Rebecca Baillie,Xianlin Han,Gabi Kastenmüller,Wei Jia,Guoxiang Xie,Shahzad Ahmad,Thomas Hankemeier,Cornelia M. van Duijn,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Andrew J. Saykin,Rima Kaddurah-Daouk +20 more
TL;DR: In this paper, the association of BAs with the "A/T/N" (amyloid, tau, and neurodegeneration) biomarkers for AD: cerebrospinal fluid (CSF), atrophy (magnetic resonance imaging), and brain glucose metabolism (FDG PET).
Journal ArticleDOI
Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers
Megan M. Bernath,Sudeepa Bhattacharyya,Kwangsik Nho,Dinesh Kumar Barupal,Oliver Fiehn,Rebecca Baillie,Shannon L. Risacher,Matthias Arnold,Tanner Y. Jacobson,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Rima Kaddurah-Daouk,Andrew J. Saykin +14 more
TL;DR: This study shows that PUTG component scores were significantly associated with diagnostic group and AD biomarkers, a finding that was more pronounced in APOE ε4 carriers.
Featured Article APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
Shannon L. Risacher,Sungeun Kim,Kwangsik Nho,Tatiana Foroud,Li Shen,Ronald C. Petersen,Clifford R. Jack,Laurel A. Beckett,Paul S. Aisen,Robert A. Koeppe,William J. Jagust,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Andrew J. Saykin +14 more
TL;DR: This study assessed apolipoprotein E (APOE) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC).
Book ChapterDOI
GN-SCCA: GraphNet Based Sparse Canonical Correlation Analysis for Brain Imaging Genetics
Lei Du,Jingwen Yan,Sungeun Kim,Shannon L. Risacher,Heng Huang,Mark Inlow,Jason H. Moore,Andrew J. Saykin,Li Shen +8 more
TL;DR: This work proposes a novel structured SCCA method using Graph constrained Elastic-Net (GraphNet) regularizer to not only discover important associations, but also induce smoothness between coefficients that are adjacent in the graph.
Posted ContentDOI
Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Neuroimaging and CSF Biomarkers
Kwangsik Nho,Alexandra Kueider-Paisley,Siamak MahmoudianDehkordi,Matthias Arnold,Shannon L. Risacher,Gregory Louie,Colette Blach,Rebecca Baillie,Xianlin Han,Gabi Kastenmüller,Wei Jia,Guoxiang Xie,Shahzad Ahmad,Thomas Hankemeier,Cornelia M. van Duijn,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Andrew J. Saykin,Rima Kaddurah-Daouk,Alzheimer’s Disease Neuroimaging Initiative +21 more
TL;DR: This is the first study to show serum-based BA metabolites are associated with “A/T/N” AD biomarkers, providing further support for a role of BA pathways in AD pathophysiology.