G
Gabi Kastenmüller
Researcher at King's College London
Publications - 185
Citations - 13864
Gabi Kastenmüller is an academic researcher from King's College London. The author has contributed to research in topics: Population & Metabolite. The author has an hindex of 47, co-authored 173 publications receiving 10324 citations. Previous affiliations of Gabi Kastenmüller include Cornell University & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
An atlas of genetic influences on human blood metabolites
So-Youn Shin,Eric B. Fauman,Ann-Kristin Petersen,Jan Krumsiek,Rita Santos,Jie Huang,Matthias Arnold,Idil Erte,Vincenzo Forgetta,Tsun-Po Yang,Klaudia Walter,Cristina Menni,Lu Chen,Lu Chen,Louella Vasquez,Ana M. Valdes,Ana M. Valdes,Craig L. Hyde,Vicky Wang,Daniel Ziemek,Phoebe M. Roberts,Li Xi,Elin Grundberg,Melanie Waldenberger,J. Brent Richards,Robert P. Mohney,Michael V. Milburn,Sally John,Jeff K. Trimmer,Fabian J. Theis,John P. Overington,Karsten Suhre,M. Julia Brosnan,Christian Gieger,Gabi Kastenmüller,Tim D. Spector,Nicole Soranzo +36 more
TL;DR: The most comprehensive exploration of genetic loci influencing human metabolism thus far, comprising 7,824 adult individuals from 2 European population studies, is reported, reporting genome-wide significant associations at 145 metabolic loci and their biochemical connectivity with more than 400 metabolites in human blood.
Journal ArticleDOI
Human metabolic individuality in biomedical and pharmaceutical research
Karsten Suhre,So-Youn Shin,Ann-Kristin Petersen,Robert P. Mohney,David Meredith,Brigitte Wägele,Elisabeth Altmaier,Panos Deloukas,Jeanette Erdmann,Elin Grundberg,Elin Grundberg,Christopher J Hammond,Martin Hrabé de Angelis,Gabi Kastenmüller,Anna Köttgen,Florian Kronenberg,Massimo Mangino,Christa Meisinger,Thomas Meitinger,Hans-Werner Mewes,Michael V. Milburn,Cornelia Prehn,Johannes Raffler,Janina S. Ried,Werner Römisch-Margl,Nilesh J. Samani,Kerrin S. Small,H.-Erich Wichmann,Guangju Zhai,Thomas Illig,Tim D. Spector,Jerzy Adamski,Nicole Soranzo,Christian Gieger +33 more
TL;DR: A comprehensive analysis of genotype-dependent metabolic phenotypes using a genome-wide association study with non-targeted metabolomics to identify genetic loci associated with blood metabolite concentrations and generates many new hypotheses for biomedical and pharmaceutical research.
Journal ArticleDOI
A genome-wide perspective of genetic variation in human metabolism
Thomas Illig,Christian Gieger,Guangju Zhai,Werner Römisch-Margl,Rui Wang-Sattler,Cornelia Prehn,Elisabeth Altmaier,Gabi Kastenmüller,Bernet S. Kato,Hans-Werner Mewes,Thomas Meitinger,Martin Hrabé de Angelis,Florian Kronenberg,Nicole Soranzo,Nicole Soranzo,H-Erich Wichmann,Tim D. Spector,Jerzy Adamski,Karsten Suhre +18 more
TL;DR: A genome-wide association study of 163 metabolic traits measured in human blood from 1,809 participants from the KORA population, with replication in 422 participants of the TwinsUK cohort, finding genetic variant is located in or near genes encoding enzymes or solute carriers whose functions match the associating metabolic traits.
Book ChapterDOI
3D Shape Histograms for Similarity Search and Classification in Spatial Databases
TL;DR: 3D shape histograms are introduced as an intuitive and powerful similarity model for 3D objects that efficiently supports similarity search based on quadratic forms and has high classification accuracy and good performance.
Journal ArticleDOI
Connecting genetic risk to disease end points through the human blood plasma proteome.
Karsten Suhre,Matthias Arnold,Aditya M. Bhagwat,Richard Cotton,Rudolf Engelke,Johannes Raffler,Hina Sarwath,Gaurav Thareja,Annika Wahl,Robert Kirk DeLisle,Larry Gold,Marija Pezer,Gordan Lauc,Mohammed A. El-Din Selim,Dennis O. Mook-Kanamori,Eman K. Al-Dous,Yasmin A. Mohamoud,Joel A. Malek,Konstantin Strauch,Harald Grallert,Annette Peters,Gabi Kastenmüller,Christian Gieger,Johannes Graumann +23 more
TL;DR: A GWAS is described using a highly multiplexed aptamer-based affinity proteomics platform to quantify 539 associations between protein levels and gene variants (pQTLs) in a German cohort and replicate over half of them in an Arab and Asian cohort.