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Shashank Gupta
Researcher at University of Copenhagen
Publications - 38
Citations - 1526
Shashank Gupta is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 19, co-authored 32 publications receiving 1289 citations. Previous affiliations of Shashank Gupta include Johns Hopkins University School of Medicine & Lund University.
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Journal ArticleDOI
High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
Thais de Castro Barbosa,Thais de Castro Barbosa,Lars R. Ingerslev,Petter S. Alm,Soetkin Versteyhe,Julie Massart,Morten Arendt Rasmussen,Ida Donkin,Rasmus J. O. Sjögren,Jonathan M. Mudry,Laurène Vetterli,Shashank Gupta,Anna Krook,Juleen R. Zierath,Juleen R. Zierath,Romain Barrès +15 more
TL;DR: Insight is provided into mechanisms by which HFD transgenerationally reprograms the epigenome of sperm cells, thereby affecting metabolic tissues of offspring throughout two generations, and induces a transcriptomic shift of the let-7c predicted targets.
Journal ArticleDOI
Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor
Shashank Gupta,Sandeep Tyagi,Deepak V. Almeida,Mariama C. Maiga,Mariama C. Maiga,Nicole C. Ammerman,William R. Bishai +6 more
TL;DR: It is found that standard TB chemotherapy plus verapamil accelerates bacterial clearance in C3HeB/FeJ mice with near sterilization, and significantly lowers relapse rates in just 4 months of treatment when compared with mice receiving standard therapy alone.
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Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis
Shashank Gupta,Keira A. Cohen,Kathryn Winglee,Mamoudou Maiga,Bassirou Diarra,William R. Bishai +5 more
TL;DR: It is found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold, and efflux may emerge as a resistance mechanism to these drugs.
Journal ArticleDOI
Beta-Cell Specific Deletion of Dicer1 Leads to Defective Insulin Secretion and Diabetes Mellitus
Martins Kalis,Caroline Bolmeson,Jonathan L.S. Esguerra,Shashank Gupta,Anna Edlund,Neivis Tormo-Badia,Dina Speidel,Dan Holmberg,Dan Holmberg,Sofia Mayans,Sofia Mayans,Nelson K. S. Khoo,Anna Wendt,Lena Eliasson,Corrado M. Cilio +14 more
TL;DR: It is demonstrated that a β-cell specific disruption of the miRNAs network, although allowing for apparently normal β- cell development, leads to progressive impairment of insulin secretion, glucose homeostasis and diabetes development.
Journal ArticleDOI
Aerosol Mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota.
Kathryn Winglee,Emiley A. Eloe-Fadrosh,Shashank Gupta,Haidan Guo,Claire M. Fraser,William R. Bishai +5 more
TL;DR: It is demonstrated that the mouse gut microbiota significantly changes with M. tuberculosis infection, with all mice showing a loss and then recovery of microbial community diversity, and that pre-infection samples clustered separately from post-infections samples, using ecological beta-diversity measures.