Sheila M. Healy

TL;DR: It is proposed that MMA(V) reductase and hGSTO 1-1 are identical proteins, which is 100% identical, over 92% of sequence that was analyzed, with the recently discovered human glutathione-S-transferase Omega class hG STO1-1.

TL;DR: The experimental results support the hypothesis that DMPS competes with endogenous ligands for MMA(III), forming a DMPS-MMA complex that is readily excreted in the urine and points out the need for studying the biochemical toxicology of MMA( III).

TL;DR: The specific activity of this critical enzyme for arsenite biotransformation was determined by incubating liver, testis, kidney, or lung cytosol of male B6C3F1 mice with sodium arsenite and S-[methyl-3H]adenosyl-L-methionine and measuring the formation of [methyl- 3H]monomethylarsonate.

TL;DR: The first-time identification of MMA( III) and DMA(III) in liver after arsenate exposure indicates that the significance of arsenic species in mammalian tissue needs to be re-examined and re-evaluated with respect to their role in the toxicity and carcinogenicity of inorganic arsenic.

TL;DR: The guinea pig, like the marmoset and tamarin monkeys and unlike most other animals studied thus far, appears to be deficient as far as the enzyme activities that methylate inorganic arsenite.