Journal ArticleDOI
DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMAIII), excreted in human urine.
H. Vasken Aposhian,Baoshan Zheng,Mary M. Aposhian,X. Chris Le,Mariano E. Cebrián,William R. Cullen,Robert A. Zakharyan,Mingsheng Ma,Richard C. Dart,Zhai Cheng,Zhai Cheng,Paul Andrewes,Luke Yip,Gerald F. O'Malley,R M Maiorino,Wayne A. Van Voorhies,Sheila M. Healy,Allison Titcomb +17 more
TLDR
The experimental results support the hypothesis that DMPS competes with endogenous ligands for MMA(III), forming a DMPS-MMA complex that is readily excreted in the urine and points out the need for studying the biochemical toxicology of MMA( III).About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2000-05-15. It has received 139 citations till now. The article focuses on the topics: Arsenic.read more
Citations
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Journal ArticleDOI
Arsenic round the world: a review.
TL;DR: This review deals with environmental origin, occurrence, episodes, and impact on human health of arsenic, a metalloid occurs naturally, being the 20th most abundant element in the earth's crust.
Journal ArticleDOI
Arsenic toxicity and potential mechanisms of action
TL;DR: A better understanding of the mechanism(s) of action) of arsenic will make a more confident determination of the risks associated with exposure to this chemical.
Journal ArticleDOI
Arsenic: toxicity, oxidative stress and human disease.
Klaudia Jomová,Zita Jenisová,Melánia Feszterová,Stanislav Baros,Líska J,Daniela Hudecová,Christopher J. Rhodes,Marian Valko +7 more
TL;DR: In this paper, the role of antioxidant defence systems against arsenic toxicity is discussed, and the role role of vitamin C (ascorbic acid), vitamin E (α-tocopherol), curcumin, glutathione and antioxidant enzymes such as superoxide dismutase, catalase, and peroxidase in their protective roles against arsenic-induced oxidative stress is also discussed.
Journal ArticleDOI
Mercury Toxicity and Treatment: A Review of the Literature
TL;DR: D diagnosis of mercury toxicity can be challenging but can be obtained with reasonable reliability and effective therapies for clinical toxicity have been described.
References
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Journal ArticleDOI
Monomethylarsonous acid (MMAIII) is more toxic than arsenite in Chang human hepatocytes.
TL;DR: Data demonstrate that MMA(III), an intermediate in in organic arsenic methylation, is highly toxic and again raises the question as to whether methylation of inorganic arsenic is a detoxication process.
Journal Article
Malignant Neoplasms among Residents of a Blackfoot Disease-endemic Area in Taiwan: High-Arsenic Artesian Well Water and Cancers
TL;DR: A dose-response relationship was observed between SMR of the cancers and blackfoot disease prevalence rate of the villages and townships in the endemic areas, and SMRs of cancers were greater in villages where only artesian wells were used as the drinking water source than in villages using both artesian and shallow wells.
Journal Article
Arsenic in groundwater in seven districts of west bengal, india : the biggest arsenic calamity in the world
Badal Kumar Mandal,P. P. Chowdhury,G. Samanta,Gautam Kumar Basu,C. R. Chanda,Dilip Lodh,N. K. Karan,R.K. Dhar,D. K. Tamili,Dipankar Das,Kshitish Chandra Saha,Dipankar Chakraborti +11 more
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Association of Arsenic-Induced Malignant Transformation with DNA Hypomethylation and Aberrant Gene Expression
Christopher Q. Zhao,Matthew R. Young,Bhalchandra A. Diwan,Timothy P. Coogan,Michael P. Waalkes +4 more
TL;DR: Results indicate arsenic can act as a carcinogen by inducing DNA hypomethylation, which in turn facilitates aberrant gene expression, and they constitute a tenable theory of mechanism in arsenic carcinogenesis.