Sheng Chen

TL;DR: Investigation of the changing role of TGF-β signaling in IVD at different pathophysiological stages and its specific molecular mechanisms are needed will contribute to safe and effective TGF -β signaling-based treatments for IVD degeneration.

TL;DR: In this article, the authors studied the effect of hypoxia inducible factor 1 subunit alpha (HIF1A) on intervertebral disc degeneration in both rats and humans.

TL;DR: It is suggested that BMSCs can protect against compression-induced apoptosis of NPCs by inhibiting the mitochondrial pathway and thus enhance the understanding on the MSC-based therapy for IVDD.

TL;DR: Under oxidative stress, RIP1/RIP3‐mediated programmed necrosis, executed through the PARP‐AIF pathway, played an important role in NP cell death, and Protective strategies aiming to regulate programmed Necrostatin‐1 may exert a beneficial effect for NP cells survival, and ultimately retard intervertebral disc degeneration.

TL;DR: TIGAR acted as an important endogenous negative regulator of ROS levels, which might inhibit compression‐induced apoptosis and autophagy through SP1‐dependent mechanisms, and established that mithramycin A could inhibit TIGAR expression and Autophagy levels in NP cells under compression conditions, while PFTα had no similar effect.