TGF-β signaling in intervertebral disc health and disease.
Reads0
Chats0
TLDR
Investigation of the changing role of TGF-β signaling in IVD at different pathophysiological stages and its specific molecular mechanisms are needed will contribute to safe and effective TGF -β signaling-based treatments for IVD degeneration.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2019-08-01 and is currently open access. It has received 72 citations till now.read more
Citations
More filters
Journal ArticleDOI
CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
Lin Xie,Weibo Huang,Zhenhua Fang,Fan Ding,Fei Zou,Xiaosheng Ma,Jie Tao,Jingkang Guo,Xinlei Xia,Hongli Wang,Zuochong Yu,Feizhou Lu,Jianyuan Jiang +12 more
TL;DR: This study provides the first evidence that circERCC2 could ameliorate IVDD through miR-182-5p/SIRT1 axis by activating mitophagy and inhibiting apoptosis, and suggests that circ ERCC2 is a potentially effective therapeutic target for IVDD.
Journal ArticleDOI
Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019
TL;DR: In this article , the authors comprehensively analyzed the global level and trends of prevalence, incidence and years lived with disability for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI).
Journal ArticleDOI
Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019
Sheng Chen,Zengwu Shao,Sheng Chen,Huiling Cao,Mingjue Chen,Huiling Cao,Xiaohao Wu,Sixiong Lin,Sixiong Lin,José Costa,Chu Tao,José Costa,Huiling Cao,Zengwu Shao,Guozhi Xiao +14 more
TL;DR: In this article, the authors comprehensively analyzed the global level and trends of prevalence, incidence and years lived with disability (YLDs) for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI).
Journal ArticleDOI
Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs
Yibo Gan,Jian He,Jun Zhu,Zhengyang Xu,Zhong Wang,Jing Yan,Ou Hu,Zhijie Bai,Lin Chen,Yangli Xie,Min Jin,Shuo Huang,Bing Liu,Bing Liu,Bing Liu,Peng Liu +15 more
TL;DR: In this article, the transcriptomic landscape of 108 108 intervertebral disks (IVDs) was mapped using single-cell RNA sequencing of three main compartments from young and adult healthy IVDs, including the nucleus pulposus (NP), annulus fibrosus, and cartilage endplate (CEP).
Journal ArticleDOI
Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc
TL;DR: In this paper , the focal adhesion protein Kindlin-2 is shown to be highly expressed in the nucleus pulposus (NP), but not in the anulus fibrosus and the cartilaginous endplates, in the IVD tissues.
References
More filters
Journal ArticleDOI
TGF-β: the master regulator of fibrosis
TL;DR: Studies over the past 5 years have identified additional mechanisms that regulate the action of TGF-β1/Smad signalling in fibrosis, including short and long noncoding RNA molecules and epigenetic modifications of DNA and histone proteins.
Journal ArticleDOI
Non-specific low back pain
TL;DR: Two treatment strategies are currently used, a stepped approach beginning with more simple care that is progressed if the patient does not respond, and the use of simple risk prediction methods to individualise the amount and type of care provided.
Journal ArticleDOI
Role of cytokines in intervertebral disc degeneration: pain and disc content.
TL;DR: An enhanced understanding of the contribution of cytokines and immune cells to these catabolic, angiogenic and nociceptive processes could provide new targets for the treatment of symptomatic disc disease.
Journal ArticleDOI
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
TL;DR: This review summarizes the recent advances in the understanding of TGF-β/BMP signaling in osteoblast differentiation, chondrocyte differentiation, skeletal development, cartilage formation, bone formation,Bone homeostasis, and related human bone diseases caused by the disruption of T GF-β / BMP signaling.
Journal ArticleDOI
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
TL;DR: TGF-β is introduced as the best-studied factor among the TGF- β family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.