Showing papers in "Osteoarthritis and Cartilage in 2019"

TL;DR: These guidelines offer comprehensive and patient-centered treatment profiles for individuals with Knee, Hip, and Polyarticular OA that are derived from expert consensus and based on objective review of high-quality meta-analytic data.

TL;DR: A systematic review of the osteoarthritis literature published in English between 2017/05/01 and 2018/04/25, with a focus on papers which have the potential to improve patient care, or which suggest novel areas for future research.

TL;DR: It is suggested that a human osteochondral plug-based model may overcome many of the fundamental limitations associated with animal and in-vitro models based on isolated cells and provide a platform for the development and testing of targeted treatment and validation of novel OA markers directly on human tissues.

TL;DR: IACs, especially continuous Iacs, may be associated with an increased risk of knee ROA progression, and the associations of IACs initiation using a propensity-score matched cohort study and continuous IAC’s using marginal structural models with therisk of kneeROA progression were examined.

TL;DR: Lorecivivint shows potential to modify structure and improve symptoms of knee OA, suggesting a novel mechanism for Wnt pathway inhibition, enhancing chondrogenesis, chondrocyte function, and anti-inflammation.

TL;DR: Weighted nationally representative data from the 2015 Medical Expenditure Panel Survey were used to estimate OA prevalence in noninstitutionalized adults and compare adults with OA to those without OA for clinical (pain interference with activities, functional limitations), humanistic, and economic outcomes (healthcare costs, wage loss).

TL;DR: The current research situation and progress of the mechanisms through which IVD stem/progenitor cells failed to repair IVD tissues during IVD degeneration are reviewed to provide an innovative research direction for endogenous repair and a new potential treatment strategy for IVd degeneration.

TL;DR: Investigation of the changing role of TGF-β signaling in IVD at different pathophysiological stages and its specific molecular mechanisms are needed will contribute to safe and effective TGF -β signaling-based treatments for IVD degeneration.

TL;DR: Different metabolic phenotypes in human synovial fluid are revealed to provide insight into pathogenesis, represent novel biomarkers, and can move toward developing personalized interventions for subgroups of OA patients.

TL;DR: This narrative review highlights a selection of studies based on their quality and perceived importance to the field mainly including those that evaluate prognostic value of biomarkers for OA progression and are innovative and uncover new candidate biomarkers, or use new approaches in biomarker discovery.

TL;DR: Serum COMP and urinary CTX-II can distinguish between knee or hip OA patients and control subjects and is effective in predicting OA progression, according to the overall results.

TL;DR: Using methods that provide a way to assess numerous variables of different types and scalings simultaneously in relation to an outcome of interest enabled a data-driven approach that identified key variables associated with a progression phenotype.

TL;DR: Severe obesity increased load-induced cartilage damage, while milder changes in adiposity/metabolic syndrome seen in TLR5KO mice did not, which suggests that the gut microbiome may influence cartilage pathology.

TL;DR: HOS-12 was a reliable and valid alternative to HOOS in THR patients with moderate to severe OA and provided three domain-specific and summary hip impact scores with substantially reduced respondent burden.

TL;DR: Degeneration-related CEP matrix changes could hinder the success of biologic therapies that require increased nutrient supply, and CEP transport properties dramatically affect NP cell survival/function.

TL;DR: The results showed that feature learning from T2 maps has potential in uncovering information that can potentially better diagnose OA than simple averages or linear patterns decomposition.

TL;DR: In this paper, the authors identified enteric dysbacteriosis as a causal factor in the initiation and propagation of obesity-associated OA in animal models, but the demonstration of causality in humans will require further studies.

TL;DR: Although the poor pain and function trajectory types tend to go together within persons, a significant number experience either poor pain or function but not both, suggesting heterogeneity among persons who do not fully benefit from KA.

TL;DR: A systematic review of systematic reviews and randomised controlled trials from the past year evaluating rehabilitation for people with osteoarthritis provides narrative synthesis of findings focused on core recommended treatments for osteoartritis.

TL;DR: Patients with knee and hip OA constitute a group of patients with an alarmingly high use of opioids, and 12% of incident opioid dispensations are attributable to OA and/or its related comorbidities.

TL;DR: TFEB overexpression suppressed TBHP-induced apoptosis and senescence via autophagic flux stimulation in NP cell and alleviates puncture-induced IVDD development in vivo.

TL;DR: The mutation of Clock promotes inflammatory activity by mediating the posttranscriptional regulation of NFκB in OA pathogenesis and is demonstrated to be a major cause of cartilage damage and inflammation.

TL;DR: Clinicians and students encounter barriers to delivery of high-value OA care in clinical practice/training (micro-level); within service environments (meso-level) and within the health system (macro-level).

TL;DR: The findings highlight the importance of developing strategies to lower the falls risk among patients following THA/TKA, and summarized both non-modifiable and modifiable risk factors for post-THA and/or TKA falls.

TL;DR: Several overarching themes in the recent literature were identified and are summarized, including new methods to detect early osteoarthritis (OA) development, and studies describing healthy and OA cartilage and biomechanics.

TL;DR: There is a higher and more consistent genetic contribution for knee OA surgery in women than men, and in men the genetic contribution was relatively low and varied with age and BMI.

TL;DR: This proof-of-concept study shows that DECT has the potential to discriminate meniscal CPP deposits from calcium HA in subchondral and trabecular bone in vivo, paving the way for the non-invasive biochemical signature assessment of intra- and juxta-articular calcium crystal deposits.

TL;DR: In this paper, the optimal mTOR inhibitor for treating human degenerative disc disease was identified, which is based on the mTOR complex 1 (mTORC1), which regulates p70/ribosomal S6 kinase, negatively regulates autophagy, and is controlled by Akt.

TL;DR: In models taking into account variables that change over time, individuals who had knee pain, alone or with knee rOA, had increased mortality, particularly strong among those obese.

TL;DR: Prioritising statements will bring focus to the future work of the Joint Effort Initiative in the future and provide a basis for longer-term actions.