S
Shenping Liu
Researcher at Pfizer
Publications - 43
Citations - 1866
Shenping Liu is an academic researcher from Pfizer. The author has contributed to research in topics: Glucokinase & Binding site. The author has an hindex of 22, co-authored 41 publications receiving 1598 citations.
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Journal ArticleDOI
Crystal Structure of the Herpes Simplex Virus 1 DNA Polymerase
Shenping Liu,John D. Knafels,Jeanne S. Chang,Gregory Allan Waszak,Eric T. Baldwin,Martin R. Deibel,Darrell R. Thomsen,Fred L. Homa,Peter A. Wells,Monica C. Tory,Roger A. Poorman,Hua Gao,Xiayang Qiu,Andrew P. Seddon +13 more
TL;DR: The first crystal structure of a herpesvirus polymerase is presented, the Herpes Simplex Virus type 1 DNA polymerase, at 2.7 Å resolution and a novel inhibition mechanism is proposed in which a representative of a series of non-nucleosidic viral polymerase inhibitors, the 4-oxo-dihydroquinolines, binds at the polymerase active site interacting non-covalently with both the polymer enzyme and the DNA duplex.
Journal ArticleDOI
Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes
Erik C. Hett,Hua Xu,Kieran F. Geoghegan,Ariamala Gopalsamy,Robert E. Kyne,Carol A. Menard,Arjun Narayanan,Mihir D. Parikh,Shenping Liu,Lee R. Roberts,Ralph P. Robinson,Michael A. Tones,Lyn H. Jones +12 more
TL;DR: This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes, illustrating the utility of sulfonyl fluoride probes designed to react with specific tyrosines of a protein and augments the chemical biology toolkit by these probes uses in target validation and molecular pharmacology.
Journal ArticleDOI
Crystal structures of interleukin 17A and its complex with IL-17 receptor A
Shenping Liu,Xi Song,Boris A. Chrunyk,Suman Shanker,Lise R. Hoth,Eric S. Marr,Matthew C. Griffor +6 more
TL;DR: The structural results are supported by biophysical studies with IL-17A variants produced by site-directed mutagenesis and the selection of a different receptor polypeptide to complete the cytokine-receptor complex.
Journal ArticleDOI
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.
Allen J. Duplantier,Stacey L. Becker,Michael John Bohanon,Kris A. Borzilleri,Boris A. Chrunyk,James T. Downs,Lain-Yen Hu,Ayman El-Kattan,Larry C. James,Shenping Liu,Jiemin Lu,Noha Maklad,Mahmoud N. Mansour,Scot Richard Mente,Mary Piotrowski,Subas M. Sakya,Sheehan Susan M,Stefanus J. Steyn,Christine A. Strick,Victoria A. Williams,Lei Zhang +20 more
TL;DR: Subsequent evaluation against the rat DAAO enzyme revealed a divergent SAR versus the human enzyme and may explain the high exposures of drug necessary to achieve significant changes in rat or mouse cerebellum D-serine.
Journal ArticleDOI
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Jeffrey A. Pfefferkorn,Angel Guzman-Perez,John Litchfield,Robert J. Aiello,Judith L. Treadway,John C. Pettersen,Martha L. Minich,Kevin J. Filipski,Christopher S. Jones,Meihua Tu,Gary Erik Aspnes,Hud Lawrence Risley,Jianwei Bian,Benjamin D. Stevens,Patricia Bourassa,Theresa D’Aquila,Levenia Baker,Nicole Barucci,Alan Robertson,Francis Bourbonais,David R. Derksen,Margit MacDougall,Over Cabrera,Jing Chen,Amanda L. Lapworth,James A. Landro,William J. Zavadoski,Karen Atkinson,Nahor Haddish-Berhane,Beijing Tan,Lili Yao,Rachel E. Kosa,Manthena V.S. Varma,Bo Feng,David B. Duignan,Ayman El-Kattan,Sharad B. Murdande,Shenping Liu,Mark Ammirati,John D. Knafels,Paul DaSilva-Jardine,Laurel Sweet,Spiros Liras,Timothy P. Rolph +43 more
TL;DR: 19 is identified as a potent glucokinase activator with a greater than 50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species, leading to its selection as a clinical development candidate for treating type 2 diabetes.