K
Karen Oegema
Researcher at University of California, San Diego
Publications - 140
Citations - 14569
Karen Oegema is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Kinetochore & Centrosome. The author has an hindex of 62, co-authored 134 publications receiving 13146 citations. Previous affiliations of Karen Oegema include University of Dundee & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
Birte Sönnichsen,Liisa Koski,Andrew Walsh,P. Marschall,Beate Neumann,M. Brehm,Anne-Marie Alleaume,J. Artelt,Paulo Bettencourt,Etienne Cassin,M. Hewitson,C. Holz,Moddasar N. Khan,S. Lazik,Charles E. Martin,Björn Nitzsche,Martine Ruer,Joanne Stamford,Maria Winzi,R. Heinkel,Marion S. Röder,J. Finell,H. Häntsch,Steven J.M. Jones,Martin R. Jones,Martin R. Jones,Fabio Piano,Kristin C. Gunsalus,Karen Oegema,Pierre Gönczy,Pierre Gönczy,Alan Coulson,Alan Coulson,Anthony A. Hyman,Christophe Echeverri +34 more
TL;DR: This work used RNA-mediated interference to target 98% of all genes predicted in the C. elegans genome in combination with differential interference contrast time-lapse microscopy and developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling to predict new functions for previously uncharacterized genes.
Journal ArticleDOI
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
Pierre Gönczy,Pierre Gönczy,Christophe Echeverri,Christophe Echeverri,Karen Oegema,Karen Oegema,A. Coulson,Steven J.M. Jones,Richard R. Copley,John Duperon,Jeff Oegema,Michael Brehm,Etienne Cassin,Eva Hannak,Matthew Kirkham,Silke Pichler,Silke Pichler,Kathrin Flohrs,Anoesjka Goessen,Sebastian A. Leidel,Anne-Marie Alleaume,Cecilie Martin,Nurhan Özlü,Peer Bork,Anthony A. Hyman,Anthony A. Hyman +25 more
TL;DR: A functional genomic screen to identify genes required for cell division in Caenorhabditis elegans using an in vivo time-lapse differential interference contrast microscopy assay and found that this screen provides putative gene functions for other species as well.
Journal ArticleDOI
Cytokinesis in animal cells
TL;DR: This review provides an overview of four topics in animal cell cytokinesis: signaling between the anaphase spindle and cortex, the mechanics of cortical remodeling, abscission, and regulation of cytokineis by the cell cycle machinery.
Journal ArticleDOI
Functional analysis of kinetochore assembly in Caenorhabditis elegans.
TL;DR: Different roles are suggested for the kinetochore and the chromosomal passengers in mitotic chromosome segregation and the recruitment of CeINCENP to chromosomes, which are independent of each other.
Journal ArticleDOI
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
TL;DR: It is suggested that aurora-A kinases are required to execute a MT-independent pathway for the recruitment of PCM during centrosome maturation, as well as for the increase in centrosomal γ-tubulin as embryos enter mitosis.