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Shie-Liang Hsieh

Researcher at Academia Sinica

Publications -  158
Citations -  7754

Shie-Liang Hsieh is an academic researcher from Academia Sinica. The author has contributed to research in topics: Decoy receptor 3 & Receptor. The author has an hindex of 42, co-authored 142 publications receiving 6930 citations. Previous affiliations of Shie-Liang Hsieh include National Yang-Ming University & Taipei Medical University.

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Isolation of multipotent mesenchymal stem cells from umbilical cord blood.

TL;DR: Surprisingly, these cells were also able to differentiate into neuroglial- and hepatocyte-like cells under appropriate induction conditions and, thus, they may be more than mesenchymal stem cells as evidenced by their ability to differentiation into cell types of all 3 germ layers.
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LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response

TL;DR: It is demonstrated that LIGHT is selectively expressed on immature dendritic cells (DCs) generated from human PBMCs, and engagement of LIGHT costimulates human T cell proliferation, amplifies the NF-κB signaling pathway, and preferentially induces the production of IFN-γ, but not IL-4, in the presence of an antigenic signal.
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CLEC5A is critical for dengue-virus-induced lethal disease.

TL;DR: The observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from d Dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.
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Isolation and characterization of size-sieved stem cells from human bone marrow

TL;DR: A culture device is used to sieve out a homogeneous population of cells (termed size‐sieved [SS] cells) from bone marrow aspirates that had the capacity for self‐renewal and the multilineage potential to form bone, fat, and cartilage, and satisfy the characteristics of MSCs.