S
Shie-Liang Hsieh
Researcher at Academia Sinica
Publications - 158
Citations - 7754
Shie-Liang Hsieh is an academic researcher from Academia Sinica. The author has contributed to research in topics: Decoy receptor 3 & Receptor. The author has an hindex of 42, co-authored 142 publications receiving 6930 citations. Previous affiliations of Shie-Liang Hsieh include National Yang-Ming University & Taipei Medical University.
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Journal ArticleDOI
Isolation of multipotent mesenchymal stem cells from umbilical cord blood.
TL;DR: Surprisingly, these cells were also able to differentiate into neuroglial- and hepatocyte-like cells under appropriate induction conditions and, thus, they may be more than mesenchymal stem cells as evidenced by their ability to differentiation into cell types of all 3 germ layers.
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LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response
Koji Tamada,Koji Shimozaki,Andrei I. Chapoval,Yifan Zhai,Jeffery Su,Su Fang Chen,Shie-Liang Hsieh,Shigekazu Nagata,Jian Ni,Lieping Chen +9 more
TL;DR: It is demonstrated that LIGHT is selectively expressed on immature dendritic cells (DCs) generated from human PBMCs, and engagement of LIGHT costimulates human T cell proliferation, amplifies the NF-κB signaling pathway, and preferentially induces the production of IFN-γ, but not IL-4, in the presence of an antigenic signal.
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CLEC5A is critical for dengue-virus-induced lethal disease.
Szu Ting Chen,Yi-Ling Lin,Ming Ting Huang,Ming Fang Wu,Shih-Chin Cheng,Huan Yao Lei,Chien-Kuo Lee,Tzyy-Wen Chiou,Chi-Huey Wong,Shie-Liang Hsieh,Shie-Liang Hsieh,Shie-Liang Hsieh +11 more
TL;DR: The observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from d Dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.
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LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.
Yifan Zhai,Ribo Guo,Tsui-Ling Hsu,Guo Liang Yu,Jian Ni,Byoung S. Kwon,Gong Wei Jiang,Jiamo Lu,Jie Tan,Meena Ugustus,Kent Carter,Lorena Rojas,Feng Zhu,Clint Lincoln,Greg Endress,Lilly Xing,Sa Wang,Kwi O. Oh,Reiner L. Gentz,Steve Ruben,Marc E. Lippman,Shie-Liang Hsieh,Dajun Yang +22 more
TL;DR: The data suggest that LIGHT triggers distinct biological responses based on the expression patterns of its receptors on the target cells and may play a role in the immune modulation and have a potential value in cancer therapy.
Journal ArticleDOI
Isolation and characterization of size-sieved stem cells from human bone marrow
Shih-Chieh Hung,Shih-Chieh Hung,Nien Jung Chen,Shie-Liang Hsieh,Hung Li,Hsiao Li Ma,Hsiao Li Ma,Wai Hee Lo +7 more
TL;DR: A culture device is used to sieve out a homogeneous population of cells (termed size‐sieved [SS] cells) from bone marrow aspirates that had the capacity for self‐renewal and the multilineage potential to form bone, fat, and cartilage, and satisfy the characteristics of MSCs.