Shigeki Momohara

TL;DR: Among patients with high disease activity, treatment with methotrexate and/or biologics and improved DAS28 scores and improved EQ-5D scores were associated with increased CCIA levels, and patients with comorbidities may not experience the same degree of benefit from recent RA treatments compared with patients without comorbridities in daily practice.

TL;DR: Female gender, younger age, high HAQ disability score, low serum levels of total protein and total cholesterol, high serum ALP levels, and NSAID use appear to be associated with vitamin D deficiency in Japanese patients with RA, as previously reported for patients of other ethnicities.

TL;DR: The results suggest that the number of orthopedic surgeries may change in response to changes in the drug therapy for RA.

TL;DR: The data suggest that interferon‐γ in combination with interleukin‐1β/tumor necrosis factor‐α activates the production of MCP‐4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/ CCL13 enhances fibroblast‐like synoviocyte proliferation by activating the extracellular signal‐regulated kinase mitogen‐activated protein kinase cascade.

TL;DR: Despite improvements in rheumatoid arthritis disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in patients with RA.