S
Shigeyoshi Sugihara
Publications - 5
Citations - 668
Shigeyoshi Sugihara is an academic researcher. The author has contributed to research in topics: Bacteriophage & Phage therapy. The author has an hindex of 5, co-authored 5 publications receiving 617 citations.
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Journal ArticleDOI
Experimental Protection of Mice against Lethal Staphylococcus aureus Infection by Novel Bacteriophage ϕMR11
Shigenobu Matsuzaki,Masaharu Yasuda,Hiroshi Nishikawa,Masayuki Kuroda,Takako Ujihara,Taro Shuin,Yu-An Shen,Zhe Jin,Shigeyoshi Fujimoto,M. D Nasimuzzaman,Hiroshi Wakiguchi,Shigeyoshi Sugihara,Tetsuro Sugiura,Shigeki Koda,Asako Muraoka,Shosuke Imai +15 more
TL;DR: The results uphold the efficacy of phage therapy against pernicious S. aureus infections in humans and suggest that phi MR11 may be a potential prototype for gene-modified, advanced therapeutic S.aureus phages.
Journal ArticleDOI
Efficient Elimination of Multidrug-Resistant Staphylococcus aureus by Cloned Lysin Derived from Bacteriophage ϕMR11
Mohammad Rashel,Jumpei Uchiyama,Takako Ujihara,Yoshio Uehara,Shu Kuramoto,Shigeyoshi Sugihara,Ken-ichi Yagyu,Asako Muraoka,Motoyuki Sugai,Keiichi Hiramatsu,Koichi Honke,Shigenobu Matsuzaki +11 more
TL;DR: Results indicate that MV-L might be useful as a powerful therapeutic agent against multidrug-resistant S. aureus infections and efficiently eliminated MRSA that had been artificially inoculated into the nares of mice.
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Isolation and characterization of a novel Enterococcus faecalis bacteriophage φEF24C as a therapeutic candidate
Jumpei Uchiyama,Mohammad Rashel,Yoshihiro Maeda,Iyo Takemura,Shigeyoshi Sugihara,Kazue Akechi,Asako Muraoka,Hiroshi Wakiguchi,Shigenobu Matsuzaki +8 more
TL;DR: Morphological and genomic analyses revealed that φEF24C is a large myovirus (classified as family Myoviridae morphotype A1) with a linear double-stranded DNA genome of c .
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T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections.
H Nishikawa,M Yasuda,Jumpei Uchiyama,Mohammad Rashel,Y Maeda,Iyo Takemura,Shigeyoshi Sugihara,Takako Ujihara,Y Shimizu,T Shuin,Shigenobu Matsuzaki +10 more
TL;DR: The present study experimentally demonstrated the therapeutic potential of phage for E. coli-induced UTIs, and T-even-related phages may be suitable candidates with which to treat them.
Journal ArticleDOI
Morphological and genetic analysis of three bacteriophages of Serratia marcescens isolated from environmental water
Kenshi Matsushita,Jumpei Uchiyama,Shin-ichiro Kato,Takako Ujihara,Hiroshi Hoshiba,Shigeyoshi Sugihara,Asako Muraoka,Hiroshi Wakiguchi,Shigenobu Matsuzaki +8 more
TL;DR: Results suggest that KSP90 and KSP100 may be candidate therapeutic phages to control S. marcescens infection.