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Shiling Hu
Researcher at Xi'an Jiaotong University
Publications - 20
Citations - 316
Shiling Hu is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Degranulation & Mast cell. The author has an hindex of 7, co-authored 20 publications receiving 123 citations.
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Journal ArticleDOI
Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus.
Nan Wang,Shengli Han,Rui Liu,Liesu Meng,Huaizhen He,Yongjing Zhang,Cheng Wang,Yanni Lv,Jue Wang,Xiaowei Li,Yuanyuan Ding,Jia Fu,Yajing Hou,Lu Wen,Weina Ma,Yingzhuan Zhan,Bingling Dai,Jie Zhang,Xiaoyan Pan,Shiling Hu,Jiapan Gao,Qianqian Jia,Liyang Zhang,Shuai Ge,Saisai Wang,Peida Liang,Tian Hu,Jiayu Lu,Xiangjun Wang,Huaxin Zhou,Wenjing Ta,Yuejin Wang,Shemin Lu,Langchong He +33 more
TL;DR: This study investigates whether CQ and HCQ could be ACE2 blockers and used to inhibit 2019-nCoV virus infection and shows that HCQ is slightly more toxic to ACE2h cells than CQ.
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Mast cell-mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent.
Rui Liu,Shiling Hu,Yongjing Zhang,Delu Che,Jiao Cao,Jue Wang,Tingting Zhao,Qianqian Jia,Nan Wang,Tao Zhang +9 more
TL;DR: Results reveal that fluoroquinolone‐induced anaphylactic reactions are mediated by mast cells through MRGPRX2, a mast cell‐specific receptor that mediates cell degranulation in anaphlyactic reactions.
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Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2.
TL;DR: DEX inhibits the entrance of SARS-CoV-2 spike pseudotyped virus into cell by binding to ACE2, and cell membrane chromatography results uncovered that DEX had a chromatographic retention.
Journal ArticleDOI
Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway.
Nan Wang,Jue Wang,Yongjing Zhang,Yingnan Zeng,Shiling Hu,Haoyun Bai,Yajing Hou,Cheng Wang,Huaizhen He,Langchong He +9 more
TL;DR: In this article, the effect of IMP on MRGPRX2 related mast cell activation in mouse peritoneal MC (MPMC), Human Laboratory of Allergic Disease 2 MCs (LAD2 cells) and MRgprx2-expressing HEK293 cells was examined.
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Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue.
TL;DR: Shikonin could be a potential antagonist of Mrgprx2, thereby inhibiting pseudo-allergic reactions through Ca2+ mobilization, and suppressed LAD2 cell degranulation via PLCγ-PKC-IP3 signaling pathway.