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Shinji Kasai
Researcher at National Institutes of Health
Publications - 109
Citations - 3807
Shinji Kasai is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Knockdown resistance. The author has an hindex of 33, co-authored 92 publications receiving 3209 citations. Previous affiliations of Shinji Kasai include University of Tsukuba & Cornell University.
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Journal ArticleDOI
Multimodal Pyrethroid Resistance in Malaria Vectors, Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. in Western Kenya
Hitoshi Kawada,Gabriel O. Dida,Kazunori Ohashi,Osamu Komagata,Shinji Kasai,Takashi Tomita,George Sonye,Yoshihide Maekawa,Cassian Mwatele,Sammy M. Njenga,Charles Mwandawiro,Noboru Minakawa,Masahiro Takagi +12 more
TL;DR: It is interesting that 2 different resistance mechanisms have developed in the 2 sibling species in the same area individually, and the cross resistance between permethrin and DDT in An.
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Overexpression of Cytochrome P450 CYP6D1 Is Associated with Monooxygenase-Mediated Pyrethroid Resistance in House Flies from Georgia☆
Shinji Kasai,Jeffrey G. Scott +1 more
TL;DR: It is suggested that increased expression of CYP6D1 in the resistant flies collected from Georgia in 1998 is due to increased transcription of the gene (as has been identified in LPR) and that CYP 6D1-mediated pyrethroid resistance is found in house flies from both New York and Georgia.
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Molecular cloning, nucleotide sequence and gene expression of a cytochrome P450 (CYP6F1) from the pyrethroid-resistant mosquito, Culex quinquefasciatus Say.
TL;DR: The deduced amino acid of CYP6F1 showed that it has conserved domains of a membrane-anchoring signal, reductase binding sites, a heme-binding site, ETLR motif and substrate recognition sites in P450s, which is strongly related to CyP6D1 involved in pyrethroid detoxification.
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P450 monooxygenases are an important mechanism of permethrin resistance in Culex quinquefasciatus Say larvae
TL;DR: Cytochrome P450 monooxygenase is clearly shown to play an important role as a mechanism of permethrin resistance in Jpal-per strain larvae.
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Symbiotic bacteria associated with stomach discs of human lice
Kayoko Sasaki-Fukatsu,Ryuichi Koga,Naruo Nikoh,Kazunori Yoshizawa,Shinji Kasai,Minoru Mihara,Mutsuo Kobayashi,Takashi Tomita,Takema Fukatsu +8 more
TL;DR: Molecular phylogenetic analysis of 16S rRNA gene sequences showed that the louse symbionts formed a distinct and well-defined clade in the Gammaproteobacteria, exhibiting AT-biased nucleotide composition and accelerated molecular evolution.