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Shinji Kasai
Researcher at National Institutes of Health
Publications - 109
Citations - 3807
Shinji Kasai is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Knockdown resistance. The author has an hindex of 33, co-authored 92 publications receiving 3209 citations. Previous affiliations of Shinji Kasai include University of Tsukuba & Cornell University.
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Journal ArticleDOI
Development of loop-mediated isothermal amplification method for detecting Wuchereria bancrofti DNA in human blood and vector mosquitoes.
Hidekazu Takagi,Makoto Itoh,Shinji Kasai,Thishan C. Yahathugoda,Mirani V. Weerasooriya,Eisaku Kimura +5 more
TL;DR: The loop-mediated isothermal amplification (LAMP) method was able to detect W. bancrofti DNA in 1000 μl of blood or in a pool of 60 mosquitoes, indicating its usefulness in detecting/monitoring W. pahangi infection in humans and vector mosquitoes in endemic areas.
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Use of isogenic strains indicates CYP9M10 is linked to permethrin resistance in Culex pipiens quinquefasciatus
TL;DR: CYP9M10 is found to be significantly over‐expressed in larvae of both permethrin‐resistant isogenic strains of C. quinquefasciatus, and is likely to be the P450 gene responsible for resistance in these strains.
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In vitro metabolism of pyriproxyfen by microsomes from susceptible and resistant housefly larvae
TL;DR: This study confirmed that microsomal cytochrome P450 monooxygenases play an important role in the pyriproxyfen resistance of the housefly, and suggested that the fat body must be as important as the gut for the metabolism of pyri proxyfen in resistant housefly larvae.
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Prevalence of kdr-like mutations associated with pyrethroid resistance in human head louse populations in Japan.
Shinji Kasai,Norihisa Ishii,Masaru Natsuaki,Hiroyuki Fukutomi,Osamu Komagata,Mutsuo Kobayashi,Takashi Tomita +6 more
TL;DR: This was the first large-scale survey of pyrethroid resistant head lice in Japan, and it was suggested that the quadruple mutant haplotype is a common feature of the kdr genes of pandemic head louse.
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House-fly cytochrome P450 CYP6D1: 5' flanking sequences and comparison of alleles.
TL;DR: A comparison of the 5' flanking sequences revealed a high degree of similarity for most regions, although differences in the sequences were identified, and the possible roles of these sequence differences in regulation of CYP6D1 expression are discussed.