S
Shinji Kasai
Researcher at National Institutes of Health
Publications - 109
Citations - 3807
Shinji Kasai is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Knockdown resistance. The author has an hindex of 33, co-authored 92 publications receiving 3209 citations. Previous affiliations of Shinji Kasai include University of Tsukuba & Cornell University.
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Journal ArticleDOI
Voltage-sensitive sodium channel mutations S989P + V1016G in Aedes aegypti confer variable resistance to pyrethroids, DDT and oxadiazines.
TL;DR: It is found that pyrethroid structure cannot be used to predict the level of resistance conferred by kdr.
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Molecular cloning and nucleotide sequenceof a cytochrome P450 cDNA from a pyrethroid-resistant mosquito, Culex quinquefasciatus Say
TL;DR: Polymerase chain reaction (PCR) using primers designed on the basis of the nucleotide sequence of the cDNA showed that mRNA encoding CYP6E1 is present in permethrin‐susceptible larvae as well as ‐resistant larvae, suggesting the ubiquitous distribution of CYP 6E1.
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CYP-mediated resistance and cross-resistance to pyrethroids and organophosphates in Aedes aegypti in the presence and absence of kdr.
TL;DR: It is found that CYP-mediated resistance alone contributes less to resistance than kdr, and that etofenprox and cyfluthrin should be avoided for A. aegypti control in areas where these two resistance mechanisms are prevalent.
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Quantitative Analysis of Proliferation and Excretion of Bartonella quintana in Body Lice, Pediculus humanus L.
Naomi Seki,Shinji Kasai,Noriko Saito,Osamu Komagata,Minoru Mihara,Toshinori Sasaki,Takashi Tomita,Tsuguo Sasaki,Mutsuo Kobayashi +8 more
TL;DR: B. quintana started proliferation in body lice 4 days after ingestion and was constantly excreted in the feces for at least 3 weeks, creating an explosive multiplication rate and active excretion that could be related to epidemics of trench fever in developed countries.
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Cis-acting mutation and duplication: History of molecular evolution in a P450 haplotype responsible for insecticide resistance in Culex quinquefasciatus.
TL;DR: A cytochrome P450 gene, Cyp9m10, is more than 200-fold overexpressed in a pyrethroid resistant strain of Culex quinquefasciatus, JPal-per, and a haplotype closely related to this duplicated Cyp 9m10 haplotype from JHB is discovered, a strain used for the recent genome project for this mosquito species.