Shinji Nakade

TL;DR: Although the specificity of 2APB with respect to the intracellular signaling system was not fully established, it is the first candidate for a membrane-penetrable modulator of Ins(1,4,5)P3 receptor, and it should be a useful tool to investigate the physiological role of the Ins(2,3,3)P2 receptor in various cells.

TL;DR: The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized IICR, but not CICR generates Ca 2+ waves and Ca2- oscillations.

TL;DR: The present findings indicate that a protein structurally homologous to the type I InsP3 receptor is localized in the caveolar structure of the plasma membrane and might be involved in the Ca2+ influx.

TL;DR: The cerebellar inositol 1,4,5-trisphosphate (InsP3) receptor is a high molecular weight glycoprotein abundantly expressed in Purkinje cells and the subunit structure of the InsP3 receptors was examined by cross-linking experiments.

TL;DR: Immunocytochemical studies and cDNA clones encoding IP3R expressed in the Xenopus oocytes revealed polarized distribution of XIP3R in the cytoplasm of the animal hemisphere in a well-organized endoplasmic reticulum-like structure and intensive localization in the perinuclear region of stage VI immature oocytes.