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Shixian Hu
Researcher at University Medical Center Groningen
Publications - 27
Citations - 288
Shixian Hu is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 12 publications receiving 83 citations.
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Journal ArticleDOI
Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
E. A. Lopera-Maya,Alexander Kurilshikov,Adriaan van der Graaf,Shixian Hu,Sergio Andreu-Sánchez,Lianmin Chen,Arnau Vich Vila,Ranko Gacesa,Trishla Sinha,Valerie Collij,Marjolein A Y Klaassen,Laura A Bolte,M. F. B. Gois,Pieter B. Neerincx,Morris A. Swertz,Hermie J. M. Harmsen,Cisca Wijmenga,Jingyuan Fu,Rinse K. Weersma,Alexandra Zhernakova,Serena Sanna +20 more
TL;DR: In this paper , a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project was performed.
Journal ArticleDOI
Characteristics and Dysbiosis of the Gut Microbiome in Renal Transplant Recipients
J Casper Swarte,Rianne M Douwes,Shixian Hu,Arnau Vich Vila,Michele F Eisenga,Marco van Londen,António W Gomes-Neto,Rinse K. Weersma,Hermie J. M. Harmsen,Stephan J. L. Bakker +9 more
TL;DR: It is shown that renal transplant recipients (RTRs) suffer from dysbiosis, a disruption in the balance of the gut microbiome, and Proton-pump inhibitors, mycophenolate mofetil, and estimated glomerular filtration rate (eGFR) are significant determinants of the Gut microbiome of RTRs.
Journal ArticleDOI
Effect of High versus Low Dairy Consumption on the Gut Microbiome: Results of a Randomized, Cross-Over Study
J Casper Swarte,Coby Eelderink,Rianne M Douwes,M. Yusof Said,Shixian Hu,Adrian Post,Ralf Westerhuis,Stephan J. L. Bakker,Hermie J. M. Harmsen +8 more
TL;DR: An HDD led to a significantly different composition of the gut microbiome, with a particularly lower abundance of F. prausnitzii and a higher abundance of S. thermophilus.
Journal ArticleDOI
Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Shixian Hu,Arnau Vich Vila,Ranko Gacesa,Valerie Collij,Christine Stevens,Jack Fu,Isaac Wong,Michael E. Talkowski,Manuel A. Rivas,Floris Imhann,Laura A Bolte,Hendrik M. van Dullemen,Gerard Dijkstra,Marijn C. Visschedijk,Eleonora A. M. Festen,Ramnik J. Xavier,Jingyuan Fu,Mark J. Daly,Cisca Wijmenga,Alexandra Zhernakova,Alexander Kurilshikov,Rinse K. Weersma +21 more
TL;DR: It is highlighted that both common and rare genetic variants affecting the immune system are key factors in shaping the gut microbiota in the context of IBD and pinpoints towards potential mechanisms for disease treatment.
Posted ContentDOI
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
E.A. Lopera-Maya,Alexander Kurilshikov,A M van der Graaf,Shixian Hu,Sergio Andreu-Sánchez,Lianmin Chen,A Vich Vila,Ranko Gacesa,Trishla Sinha,Valerie Collij,Marjolein A Y Klaassen,Laura A Bolte,M.F. Brandao Gois,Pieter B. Neerincx,Morris A. Swertz,Hermie J. M. Harmsen,Cisca Wijmenga,Jingyuan Fu,Rinse K. Weersma,Alexandra Zhernakova,Serena Sanna,Serena Sanna +21 more
TL;DR: A genome-wide association study within the Dutch Microbiome Project, a population cohort of 7,738 individuals from the northern Netherlands, found two robust, study-wide significant signals near the LCT and ABO genes were found to affect multiple microbial taxa and pathways, and were replicated in two independent cohorts.