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Shixing Tang
Researcher at Center for Biologics Evaluation and Research
Publications - 57
Citations - 1373
Shixing Tang is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 20, co-authored 38 publications receiving 1177 citations. Previous affiliations of Shixing Tang include National Institutes of Health & Food and Drug Administration.
Papers
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Journal ArticleDOI
Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants That Exhibit Aberrant Core Morphology and Are Blocked in Initiation of Reverse Transcription in Infected Cells
Shixing Tang,Tsutomu Murakami,Beth E. Agresta,Stephen Campbell,Eric O. Freed,Judith G. Levin +5 more
TL;DR: The data indicate that the mutations made in this study disrupt CA structure and prevent proper maturation of virus cores, and it is proposed that this results in a defect in core stability or in an early postentry event preceding reverse transcription.
Journal ArticleDOI
Nanoparticle-based immunoassays for sensitive and early detection of HIV-1 capsid (p24) antigen
Shixing Tang,Indira Hewlett +1 more
TL;DR: The results demonstrate that the HIV-1 p24 BCA assay offers 100-150-fold enhancement in the detection limit over the traditional colorimetric ELISA and indicate that the universal labeling technology based on NPs and its application may provide a rapid and sensitive testing platform for clinical diagnosis and laboratory research.
Journal ArticleDOI
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.
Shixing Tang,Mahtab Moayeri,Zhaochun Chen,Harri Härmä,Jiangqin Zhao,Haijing Hu,Robert H. Purcell,Stephen H. Leppla,Indira Hewlett +8 more
TL;DR: The results indicate that the universal labeling technology based on europium nanoparticles and its application may provide a rapid and sensitive testing platform for clinical diagnosis and laboratory research.
Journal ArticleDOI
Nanoparticle-Based biobarcode amplification assay (BCA) for sensitive and early detection of human immunodeficiency type 1 capsid (p24) antigen.
Shixing Tang,Jiangqin Zhao,James J. Storhoff,Philip J. Norris,Richard F. Little,Robert Yarchoan,Susan L. Stramer,Tim Patno,Marc Domanus,Arindam Dhar,Arindam Dhar,Chad A. Mirkin,Indira Hewlett +12 more
TL;DR: Preliminary evaluation based on testing a small number of samples indicates that the HIV-1 p24 antigen BCA may provide a new tool for sensitive and early detection of HIV-2 capsid antigen in settings where HIV- 1 RNA testing is currently not routinely performed.
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Ultrasensitive detection of HIV-1 p24 antigen using nanofunctionalized surfaces in a capacitive immunosensor.
TL;DR: An ultrasensitive capacitive immunosensor that is capable of detecting subattogram per milliliter concentrations of p24 antigen, which to the authors' knowledge is the lowest level of detection ever reported.