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Shizhong Bu
Researcher at Ningbo University
Publications - 32
Citations - 499
Shizhong Bu is an academic researcher from Ningbo University. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 11, co-authored 32 publications receiving 283 citations.
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Journal ArticleDOI
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus.
TL;DR: Ferroptosis is a form of non-optotic regulated cell death (RCD) which features iron-dependent lipid peroxide accumulation accompanied by inadequate redox enzymes, especially glutathione peroxidase 4 (GPX4) as discussed by the authors.
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Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.
Jiang Li,Mohammed Ghazwani,Ke Liu,Yixian Huang,Na Chang,Jie Fan,Fengtian He,Liying Li,Shizhong Bu,Wen Xie,Xiaochao Ma,Song Li +11 more
TL;DR: It is demonstrated that the proliferation of HSCs is critically dependent on glutamine that is used to generate α-ketoglutarate (α-KG) and non-essential amino acid (NEAA) and that strategies that are targeted at glutamine metabolism may represent a novel therapeutic approach to the treatment of liver fibrosis.
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Elevated CpG island methylation of GCK gene predicts the risk of type 2 diabetes in Chinese males.
Linlin Tang,Huadan Ye,Qingxiao Hong,Lingyan Wang,Qinwen Wang,Hongwei Wang,Leiting Xu,Shizhong Bu,Lina Zhang,Jia Cheng,Panpan Liu,Yanping Le,Meng Ye,Yifeng Mai,Shiwei Duan +14 more
TL;DR: The results showed that elevated GCK CpG4 methylation might suggest a risk of T2D in Chinese males, and gender disparity inGCK C pG4methylation might provide a clue to elaborate the pathogenesis of T1D.
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Obesity-associated digestive cancers: A review of mechanisms and interventions:
TL;DR: Evidence that obesity-related gene mutations, insulin and insulin-like growth factor signaling pathways, chronic inflammation, and altered adipokine levels often function interdependently rather than independently in carcinogenesis is presented.
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High glucose induces epithelial‑mesenchymal transition and results in the migration and invasion of colorectal cancer cells
Jiayan Wu,Jiayi Chen,Yang Xi,Fuyan Wang,Hongcun Sha,Lin Luo,Yabin Zhu,Xiaoming Hong,Shizhong Bu +8 more
TL;DR: It is suggested that hyperglycemia promotes EMT, proliferation, migration and invasion in CRC cells and may provide novel insights into the link between HG and CRC.