S
Shogo Oka
Researcher at Kyoto University
Publications - 116
Citations - 3746
Shogo Oka is an academic researcher from Kyoto University. The author has contributed to research in topics: Epitope & Glycoprotein. The author has an hindex of 34, co-authored 116 publications receiving 3590 citations. Previous affiliations of Shogo Oka include RMIT University & Osaka Bioscience Institute.
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Journal ArticleDOI
Inflammatory factors stimulate expression of group ii phospholipase a2 in rat cultured astrocytes : two distinct pathways of the gene expression
Shogo Oka,Hitoshi Arita +1 more
TL;DR: The results suggest that PLA2-II in the brain plays important roles in the inflammatory response, and conclude that the TNF-activated pathway differs from the LPS-activated one: the former is enhanced by cAMP and the latter involves protein kinase C.
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Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
Hiroshi Kitagawa,Yuko Tone,Jun-ichi Tamura,Klaus W. Neumann,Tomoya Ogawa,Shogo Oka,Toshisuke Kawasaki,Kazuyuki Sugahara +7 more
TL;DR: Results indicate that this new member of the glucuronyltransferase gene family is the enzyme previously described as glucurONYl transferase I that forms the glycosaminoglycan-protein linkage region, GlcAβ1–3Galβ1 –3Gal β1–4Xylβ1-O-Ser, of proteoglycans.
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Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site.
TL;DR: This work reports a novel PLA2 action on the proliferation of Swiss 3T3 fibroblasts via specific binding sites of approximately Mr 200,000 and is the first to offer a new viewpoint on the effect of mammalian extracellular PLA2 on cellular function.
Journal ArticleDOI
Cloning and functional expression of a novel glucuronyltransferase involved in the biosynthesis of the carbohydrate epitope HNK-1
Koji Terayama,Shogo Oka,Takashi Seiki,Yukari Miki,Akemi Nakamura,Yasunori Kozutsumi,Koji Takio,Toshisuke Kawasaki +7 more
TL;DR: Transfection of the glucuronyltransferase cDNA into COS-1 cells induced not only expression of the H NK-1 epitope on the cell surface but also marked morphological changes of the cells, suggesting that the HNK- 1 epitope associates with the cell-substratum interaction.
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Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning.
Shoji Yamamoto,Shogo Oka,Mitsuhiro Inoue,Misa Shimuta,Toshiya Manabe,Hideki Takahashi,Masaomi Miyamoto,Masahide Asano,Junko Sakagami,Katsuko Sudo,Yoichiro Iwakura,Katsuhiko Ono,Toshisuke Kawasaki +12 more
TL;DR: It is shown that the loss of a single non-reducing terminal carbohydrate residue attenuates brain higher functions in mice generated with a targeted deletion of the GlcAT-P gene.