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Shuhei Matsuoka
Researcher at Baylor College of Medicine
Publications - 15
Citations - 11704
Shuhei Matsuoka is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 14, co-authored 15 publications receiving 11194 citations. Previous affiliations of Shuhei Matsuoka include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka,Bryan A. Ballif,Agata Smogorzewska,Agata Smogorzewska,E. Robert McDonald,Kristen E. Hurov,Ji Luo,Corey E. Bakalarski,Zhenming Zhao,Nicole L. Solimini,Yaniv Lerenthal,Yosef Shiloh,Steven P. Gygi,Stephen J. Elledge +13 more
TL;DR: A large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR is performed and more than 900 regulated phosphorylation sites encompassing over 700 proteins are identified.
Journal ArticleDOI
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
Qinghua Liu,Saritha Guntuku,Xian Shu Cui,Shuhei Matsuoka,David Cortez,Katsuyuki Tamai,Guangbin Luo,Sandra Carattini-Rivera,Francisco J. DeMayo,Allan Bradley,Lawrence A. Donehower,Stephen J. Elledge +11 more
TL;DR: It is shown that in human cells, Chk1 is phosphorylated on serine 345 (S345) in response to UV, IR, and hydroxyurea (HU).
Journal ArticleDOI
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
TL;DR: Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosac charomyces pombe Cds1 protein kinases required for the DNA damage and replication checkpoints, was identified and phosphorylated and activated in response to replication blocks and DNA damage.
Journal ArticleDOI
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Atsushi Hirao,Young-Yun Kong,Shuhei Matsuoka,Andrew Wakeham,Jürgen Ruland,Hiroki Yoshida,Dou Liu,Stephen J. Elledge,Tak W. Mak +8 more
TL;DR: Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding, and provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage.
Journal ArticleDOI
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Shuhei Matsuoka,Michael C. Edwards,Chang Bai,Susan B. Parker,Pumin Zhang,Antonio Baldini,J W Harper,Stephen J. Elledge +7 more
TL;DR: The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.