N
Ni-Huiping Son
Researcher at New York University
Publications - 15
Citations - 984
Ni-Huiping Son is an academic researcher from New York University. The author has contributed to research in topics: CD36 & Endothelial stem cell. The author has an hindex of 9, co-authored 13 publications receiving 779 citations. Previous affiliations of Ni-Huiping Son include Columbia University.
Papers
More filters
Journal ArticleDOI
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Ni-Huiping Son,Tae-Sik Park,Haruyo Yamashita,Masayoshi Yokoyama,Lesley Ann Huggins,Kazue Okajima,Shunichi Homma,Matthias Szabolcs,Li-Shin Huang,Ira J. Goldberg +9 more
TL;DR: Transgenic mice expressing PPARgamma1 in the heart via the cardiac alpha-myosin heavy chain (alpha-MHC) promoter developed a dilated cardiomyopathy associated with increased lipid and glycogen stores, distorted architecture of the mitochondrial inner matrix, and disrupted cristae.
Journal ArticleDOI
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
Philip L.S.M. Gordts,Ryan Nock,Ni-Huiping Son,Bastian Ramms,Irene Lew,Jon C. Gonzales,Bryan E. Thacker,Debapriya Basu,Richard G. Lee,Adam E. Mullick,Mark J. Graham,Ira J. Goldberg,Rosanne M. Crooke,Joseph L. Witztum,Jeffrey D. Esko +14 more
TL;DR: The data indicate that ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 axis.
Journal ArticleDOI
Endothelial cell CD36 optimizes tissue fatty acid uptake
Ni-Huiping Son,Debapriya Basu,Dmitri Samovski,Terri A. Pietka,Vivek S. Peche,Florian Willecke,Xiang Fang,Shuiqing Yu,Diego Scerbo,Hye Rim Chang,Fei Sun,Svetlana Bagdasarov,Konstantinos Drosatos,Steve T Yeh,Adam E. Mullick,Kooresh I. Shoghi,Namrata Gumaste,Kyeong Jin Kim,Lesley-Ann Huggins,Tenzin Lhakhang,Nada A. Abumrad,Ira J. Goldberg +21 more
TL;DR: It is shown that EC CD36 acts as a gatekeeper for parenchymal cell FA uptake, with important downstream effects on glucose utilization and insulin action.
Journal ArticleDOI
Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice
Konstantinos Drosatos,Raffay S. Khan,Chad M. Trent,Hongfeng Jiang,Ni-Huiping Son,William S. Blaner,Shunichi Homma,P. Christian Schulze,Ira J. Goldberg +8 more
TL;DR: In this paper, Escherichia coli lipopolysaccharide (LPS) administered to C57BL/6 mice (wild type) induced cardiac dysfunction and reduced fatty acid oxidation and mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α and its downstream targets within 6-8 hours.
Journal ArticleDOI
Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure
Li Liu,Chad M. Trent,Xiang Fang,Ni-Huiping Son,Hongfeng Jiang,William S. Blaner,Yunying Hu,Yuxin Yin,Robert V. Farese,Shunichi Homma,Andrew V. Turnbull,Jan W. Eriksson,Shi-Lian Hu,Henry N. Ginsberg,Li-Shin Huang,Ira J. Goldberg,Ira J. Goldberg +16 more
TL;DR: In this paper, the authors showed that DGAT1 loss alone affects heart function, and they created cardiomyocyte-specific DAT1 knock-out (hDgat1−/−) mice.