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Shuji Ueda
Researcher at Osaka University
Publications - 22
Citations - 430
Shuji Ueda is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Lymphoma. The author has an hindex of 8, co-authored 18 publications receiving 399 citations. Previous affiliations of Shuji Ueda include Jikei University School of Medicine.
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Journal ArticleDOI
Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells.
Hanako Daino,Itaru Matsumura,Koji Takada,Junko Odajima,Hirokazu Tanaka,Shuji Ueda,Hirohiko Shibayama,Hirokazu Ikeda,Masahiko Hibi,Takashi Machii,Toshio Hirano,Yuzuru Kanakura +11 more
TL;DR: The results suggest that extracellular Ub was incorporated into hematopoietic cells and mediated their growth suppression and apoptosis through proteasome-dependent degradation of selective cellular proteins such as STAT3.
Journal ArticleDOI
Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration
Shuji Ueda,Masao Mizuki,Hirokazu Ikeda,Tohru Tsujimura,Itaru Matsumura,Kazushi Nakano,Hanako Daino,Zen-ichiro Honda,Junko Sonoyama,Hirohiko Shibayama,Hiroyuki Sugahara,Takashi Machii,Yuzuru Kanakura +12 more
TL;DR: Results indicate that 2 major KIT signaling pathways lead to cell migration, one is Y567-SFK-p38 MAPK- Ca(2+) influx-Erk and the other is Y719-PI3K-Ca( 2+) influx.
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Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation.
Koji Hashimoto,Itaru Matsumura,Tohru Tsujimura,Dae-Ki Kim,Hideki Ogihara,Hirokazu Ikeda,Shuji Ueda,Masao Mizuki,Hiroyuki Sugahara,Hirohiko Shibayama,Yukihiko Kitamura,Yuzuru Kanakura +11 more
TL;DR: It is demonstrated that Tyr719 is crucial for constitutive activation of KIT(Val814), but not for the ligand-induced activation ofKIT(WT), and that the downstream signaling of PI3-K plays an important role in lig and-independent growth and tumorigenicity by KIT (Val 814).
Journal ArticleDOI
Natural killer cell-derived large granular lymphocyte lymphoma of lung developed in a patient with hypersensitivity to mosquito bites and reactivated Epstein-Barr virus infection.
Masao Mizuki,Shuji Ueda,Shinichi Tagawa,Hirohiko Shibayama,Y Nishimori,Masaru Shibano,Hideo Asada,Masato Tanaka,Shigekazu Nagata,Urara Koudera,Kenichi Suzuki,Takashi Machii,Masahiko Ohsawa,Katsuyuki Aozasa,Teruo Kitani,Yuzuru Kanakura +15 more
TL;DR: In the pleural effusion of the present case, abnormally high levels of soluble Fas ligand, interleukin‐10 and interferon γ were detected, reflecting the microenvironment of lymphoma cells, may play a role in the progression of the lymphoma and organ injury in the lung.
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Constitutively Activated Rho Guanosine Triphosphatases Regulate the Growth and Morphology of Hairy Cell Leukemia Cells
Xian Zhang,Takashi Machii,Itaru Matsumura,Sachiko Ezoe,Akira Kawasaki,Hirokazu Tanaka,Shuji Ueda,Hiroyuki Sugahara,Hirohiko Shibayama,Masao Mizuki,Yuzuru Kanakura +10 more
TL;DR: Results indicated that constitutively activated Rho GTPases regulate the growth and unique morphology of HCL cells.