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Shuuhei Hirose
Researcher at Doshisha University
Publications - 4
Citations - 31
Shuuhei Hirose is an academic researcher from Doshisha University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 12 citations.
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NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
Tsuyoshi Waku,Nanami Nakamura,Misaki Koji,Hidenori Watanabe,Hiroki Katoh,Chika Tatsumi,Natsuko Tamura,Atsushi Hatanaka,Atsushi Hatanaka,Shuuhei Hirose,Hiroyuki Katayama,Misato Tani,Yuki Kubo,Jun Hamazaki,Takao Hamakubo,Akira Watanabe,Shigeo Murata,Akira Kobayashi +17 more
TL;DR: The results suggest that the NRF3-POMP-20S proteasome assembly axis is significant for cancer development via ubiquitin-independent proteolysis of tumor suppressor proteins.
Journal ArticleDOI
NRF3 activates mTORC1 arginine-dependently for cancer cell viability
Shuuhei Hirose,Tsuyoshi Waku,Misato Tani,Haruka Masuda,Keiko Endo,Sanae Ashitani,Iori Aketa,H. Kitano,Sota Nakada,Ayaka Wada,Atsushi Hatanaka,Tsuyoshi Osawa,Tomoyoshi Soga,Akira Kobayashi +13 more
TL;DR: In this paper , the authors showed that NRF3 contributes to cancer cell viability through mTORC1 activation in response to amino acids, particularly arginine, and that the aberrant upregulation of the axis caused tumor growth and poor prognosis.
Journal ArticleDOI
The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation.
Tsuyoshi Waku,Sota Nakada,Haruka Masuda,Haruna Sumi,Ayaka Wada,Shuuhei Hirose,Iori Aketa,Akira Kobayashi +7 more
TL;DR: In this article , the CNC-family transcription factor Nrf3 was shown to regulate macropinocytosis and autophagy to coordinate melanogenesis cascade in response to an exogenous inducer of melanin production, forskolin, upregulates the core melanogenic gene circuit, which includes Mitf, Tyr, Tyrp1, Pmel and Oca2.