S
Shweta Rane
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 7
Citations - 1391
Shweta Rane is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Gene silencing & Downregulation and upregulation. The author has an hindex of 6, co-authored 7 publications receiving 1327 citations.
Papers
More filters
Journal ArticleDOI
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
Shweta Rane,Minzhen He,Danish Sayed,Himanshu Vashistha,Ashwani Malhotra,Junichi Sadoshima,Dorothy E. Vatner,Stephen F. Vatner,Maha Abdellatif +8 more
TL;DR: It is reported here that miR-199a is acutely downregulated in cardiac myocytes on a decline in oxygen tension and this reduction is required for the rapid upregulation of its target, hypoxia-inducible factor (Hif)-1α.
Journal ArticleDOI
MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths
Danish Sayed,Shweta Rane,Jacqueline Lypowy,Minzhen He,Ieng-Yi Chen,Himanshu Vashistha,Lin Yan,Ashwani Malhotra,Dorothy E. Vatner,Maha Abdellatif +9 more
TL;DR: It is proposed that an increase in miR-21 enhances the formation of various types of cellular protrusions through directly targeting and down-regulating SPRY2.
Journal ArticleDOI
MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand
TL;DR: It is demonstrated here for the first time that miR-21 is positively regulated via an AKT-dependent pathway, which is depressed during prolonged hypoxia, and identified a unique aspect of the function of AKT by which it inhibits apoptosis through mi R-21-dependent suppression of FasL.
Journal ArticleDOI
An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p.
TL;DR: Activation of beta-adrenergic signaling counteracts the survival effects of the AKT pathway via upregulating miR-199a-5p and their role in myocyte survival during hypoxia is delineated.
Journal ArticleDOI
MicroRNA with a MacroFunction.
TL;DR: The views on how the functions of miRNA conform to existing knowledge on post-transcriptional regulation of gene expression and disease mechanisms are shared, and their potential as biomarkers and therapeutic targets in diseases are shared.