S
Shyama Sidique
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 7
Citations - 276
Shyama Sidique is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Allosteric regulation & Metabotropic glutamate receptor. The author has an hindex of 6, co-authored 7 publications receiving 261 citations. Previous affiliations of Shyama Sidique include Conrad Hotels & Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Shyama Sidique,Robert Ardecky,Ying Su,Sonoko Narisawa,Brock Brown,José Luis Millán,Eduard Sergienko,Nicholas D. P. Cosford +7 more
TL;DR: The design, synthesis and in vitro evaluation of a series of pyrazole derivatives of a screening hit which are potent TNAP inhibitors exhibiting IC(50) values as low as 5nM are reported.
Journal ArticleDOI
Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
Shyama Sidique,Sergey A. Shiryaev,Boris I. Ratnikov,Ananda Herath,Ananda Herath,Ying Su,Ying Su,Alex Y. Strongin,Nicholas D. P. Cosford,Nicholas D. P. Cosford +9 more
TL;DR: The design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium are reported.
Journal ArticleDOI
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.
Raveendra-Panickar Dhanya,Shyama Sidique,Douglas J. Sheffler,Hilary Highfield Nickols,Ananda Herath,Li Yang,Russell Dahl,Robert Ardecky,Svetlana Semenova,Athina Markou,P. Jeffrey Conn,Nicholas D. P. Cosford +11 more
TL;DR: The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.
Journal ArticleDOI
Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation
Eduard Sergienko,Jian Xu,Wallace Liu,Russell Dahl,David A Critton,Ying Su,Brock Brown,Xochella Chan,Li Yang,Ekaterina V. Bobkova,Stefan Vasile,Hongbin Yuan,Justin Rascon,Sharon Colayco,Shyama Sidique,Nicholas D. P. Cosford,Thomas D.Y. Chung,Tomas Mustelin,Rebecca Page,Paul J. Lombroso,Lutz Tautz +20 more
TL;DR: This compound is utilizes this compound to show that pharmacological inhibition of HePTP not only augments but also prolongs activation of ERK1/2 and, especially, p38 in human T cells.
Journal ArticleDOI
Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence
Shyama Sidique,Raveendra-Panickar Dhanya,Douglas J. Sheffler,Hilary Highfield Nickols,Li Yang,Russell Dahl,Arianna Mangravita-Novo,Layton H. Smith,Manoranjan S. D’Souza,Svetlana Semenova,P. Jeffrey Conn,Athina Markou,Nicholas D. P. Cosford +12 more
TL;DR: The data, showing for the first time efficacy of an mGlu(2) receptor PAM in this in vivo model, suggest potential utility for the treatment of nicotine dependence in humans.