S
Stefan Vasile
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 37
Citations - 1315
Stefan Vasile is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Apoptosis & Unfolded protein response. The author has an hindex of 16, co-authored 35 publications receiving 1192 citations. Previous affiliations of Stefan Vasile include University of Pittsburgh & Conrad Hotels.
Papers
More filters
Journal Article
The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function.
Dirk B. Mendel,Randall E. Schreck,David C. West,Guangmin Li,Laurie M. Strawn,Sheila S. Tanciongco,Stefan Vasile,Laura K. Shawver,Julie M. Cherrington +8 more
TL;DR: The durability of the in vitro activity of SU5416 was shown to be attributable to its long-lasting ability to specifically inhibit VEGF-dependent phosphorylation of Flk-1/KDR and subsequent downstream signaling, althoughSU5416 is not an irreversible inhibitor of FlKDR tyrosine kinase activity.
Journal ArticleDOI
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.
Inki Kim,Chih-Wen Shu,Wenjie Xu,Chung Wai Shiau,Daniel Grant,Stefan Vasile,Nicholas D. P. Cosford,John C. Reed +7 more
TL;DR: An essential role for ASK1 in cell death induced by ER stress is demonstrated, and the compounds identified may prove useful for revealing endogenous mechanisms that regulate inhibitory phosphorylation ofASK1.
Journal ArticleDOI
LYP inhibits T-cell activation when dissociated from CSK.
Torkel Vang,Wallace Liu,Laurence Delacroix,Shuangding Wu,Stefan Vasile,Russell Dahl,Li-Li Yang,Lucia Musumeci,Dana M. Francis,Johannes Landskron,Kjetil Taskén,Michel L. Tremblay,Benedicte A. Lie,Rebecca Page,Tomas Mustelin,Tomas Mustelin,Souad Rahmouni,Robert C. Rickert,Lutz Tautz +18 more
TL;DR: It is demonstrated that dissociation of this LYP/CSK complex is necessary for recruitment of LYP to the plasma membrane, where it down-modulates TCR signaling.
Journal ArticleDOI
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Jing Li,Tanya R. Yakushi,Francesco Parlati,Andrew L. Mackinnon,Christian Perez,Yuyong Ma,Kyle P. Carter,Sharon A. Colayco,Gavin Magnuson,Brock T. Brown,Kevin Nguyen,Stefan Vasile,Eigo Suyama,Layton H. Smith,Eduard Sergienko,Anthony B. Pinkerton,Thomas D.Y. Chung,Amy E. Palmer,Ian Pass,Sonja Hess,Seth M. Cohen,Raymond J. Deshaies +21 more
TL;DR: Identification of capzimin offers an alternative path to develop proteasome inhibitors for cancer therapy and shows >5-fold selectivity for Rpn11 over the related JAMM proteases and >2 logs selectivity over several other metalloenzymes.
Journal ArticleDOI
Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma
Sabiha Abbas,Anindita Bhoumik,Russell Dahl,Stefan Vasile,Stan Krajewski,Nicholas D. P. Cosford,Ze'ev Ronai +6 more
TL;DR: Two compounds, celastrol (CSL) and acetyl isogambogic acid, could, within a low micromolar range, efficiently elicit cell death in melanoma cells and may therefore offer new approaches for the treatment of this tumor type.