Silvano Sacco

TL;DR: Results indicate that signaling through gp130 mediates potentiation of IL-1 activities, and that gp130-dependent cytokines may be important feedback regulators of inflammation through the activation of the hypothalamus-pituitary-adrenal axis and the potentiated of acute-phase protein synthesis.

TL;DR: The air pouch seems to be a good model for studying the regulation of the early events of local inflammation, particularly the role of cytokines and cell migration in the first phase of the inflammatory process.

TL;DR: In mice, UCN significantly reduced lipopolysaccharide-induced serum tumor necrosis factor (TNF) and interleukin (IL)-1β levels in vivo but did not affect serum IL-6, and the in vivo inhibition of LPS-induced IL-1β by UCN was reversed by cyanoketone, indicating that the increase of endogenous glucocorticoids might be more important in IL- 1β inhibition than in TNF inhibition.

TL;DR: Melatonin exerted its inhibitory effect in adrenalectomized or hypophysectomized mice also, indicating that its effect is independent of the hypothalamus-pituitary-adrenal axis.

TL;DR: It is demonstrated that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation.