Silvia Volpe

TL;DR: It is shown that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors, and phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD 44v6 CR-C SCs and reduced metastatic growth.

TL;DR: It is suggested that inhibition of glycolysis may be a potentially effective strategy to target BCSCs, and functional validation of proteomic and metabolic data provide evidences for increased activities of key enzymes of anaerobic glucose fate in cancer stem cells as well as different redox status.

TL;DR: Observations indicate that during chemotaxis CCR2 acts as scavenger consuming the chemokine forming the attracting cue, and cycles rapidly back to the plasma membrane to maintain high responsiveness after relocation of the source of attractant.

TL;DR: This study indicates that the recently proposed paradigm of cAMP signaling by internalized G protein-coupled receptors is implicated in receptor function and is physiologically relevant.

TL;DR: It is reported that miR-205-5p is highly expressed in BCSCs and represses directly ERBB2 and indirectly EGFR leading to resistance to targeted therapy and it is shown that p63 directly regulates the expression of p63 which is in turn involved in the EGFR expression suggesting a miR/p63/EGFR regulation.