A
Antonina Benfante
Researcher at University of Palermo
Publications - 16
Citations - 1093
Antonina Benfante is an academic researcher from University of Palermo. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 12, co-authored 16 publications receiving 904 citations.
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Journal ArticleDOI
CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
Matilde Todaro,Miriam Gaggianesi,Veronica Catalano,Antonina Benfante,Flora Iovino,Mauro Biffoni,Tiziana Apuzzo,Isabella Sperduti,Silvia Volpe,Gianfranco Cocorullo,Gaspare Gulotta,Francesco Dieli,Ruggero De Maria,Giorgio Stassi +13 more
TL;DR: It is shown that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors, and phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD 44v6 CR-C SCs and reduced metastatic growth.
Journal ArticleDOI
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging.
Luca Tirinato,Carlo Liberale,Simone Di Franco,Simone Di Franco,Patrizio Candeloro,Antonina Benfante,Rosanna La Rocca,Lisette Potze,Roberto Marotta,Roberta Ruffilli,Vijayakumar P. Rajamanickam,Mario Malerba,Francesco De Angelis,Andrea Falqui,Ennio Carbone,Matilde Todaro,Jan Paul Medema,Giorgio Stassi,Enzo Di Fabrizio +18 more
TL;DR: It is shown that high levels of lipid droplets (LDs) are a distinctive mark of CSCs in colorectal (CR) cancer, and this increased lipid content was clearly revealed by label‐free Raman spectroscopy and it directly correlates with well‐accepted CR‐CSC markers as CD133 and Wnt pathway activity.
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Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling
Veronica Catalano,Monica Dentice,Raffaele Ambrosio,Cristina Luongo,R. Carollo,Antonina Benfante,Matilde Todaro,Giorgio Stassi,Domenico Salvatore +8 more
TL;DR: It is found that increased intracellular thyroid hormone concentration through D3 depletion induced cell differentiation and sharply mitigated tumor formation, and it is demonstrated that BMP4 is a direct thyroid hormone target and is involved in a positive autoregulatory feedback loop that modulates thyroid hormone signaling.
Journal ArticleDOI
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
Michele Milella,Italia Falcone,Fabiana Conciatori,Silvia Matteoni,Andrea Sacconi,Teresa De Luca,Chiara Bazzichetto,Vincenzo Corbo,Michele Simbolo,Isabella Sperduti,Antonina Benfante,Anais Del Curatolo,Ursula Cesta Incani,Federico Malusa,Adriana Eramo,Giovanni Sette,Aldo Scarpa,Marina Konopleva,Michael Andreeff,James A. McCubrey,Giovanni Blandino,Matilde Todaro,Giorgio Stassi,Ruggero De Maria,Francesco Cognetti,Donatella Del Bufalo,Ludovica Ciuffreda +26 more
TL;DR: Results show that PTEN-loss is a crucial determinant of synergistic interactions between MAPK and PI3K pathway inhibitors, potentially exploitable for the selection of cancer patients at the highest chance of benefit from combined therapeutic strategies.
Journal ArticleDOI
IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition.
Miriam Gaggianesi,Alice Turdo,Aurora Chinnici,Elisa Lipari,Tiziana Apuzzo,Antonina Benfante,Isabella Sperduti,Simone Di Franco,Serena Meraviglia,Elena Lo Presti,Francesco Dieli,Valentina Caputo,Gabriella Militello,Salvatore Vieni,Giorgio Stassi,Matilde Todaro +15 more
TL;DR: The role of IL4 in promoting breast cancer aggressiveness and how its targeting may improve the efficacy of current therapies was showed and the number of IFNγ-positive CTLs enhanced.