T
Tiziana Apuzzo
Researcher at University of Palermo
Publications - 15
Citations - 1631
Tiziana Apuzzo is an academic researcher from University of Palermo. The author has contributed to research in topics: Stem cell & Cancer stem cell. The author has an hindex of 12, co-authored 15 publications receiving 1360 citations.
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Journal ArticleDOI
CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
Matilde Todaro,Miriam Gaggianesi,Veronica Catalano,Antonina Benfante,Flora Iovino,Mauro Biffoni,Tiziana Apuzzo,Isabella Sperduti,Silvia Volpe,Gianfranco Cocorullo,Gaspare Gulotta,Francesco Dieli,Ruggero De Maria,Giorgio Stassi +13 more
TL;DR: It is shown that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors, and phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD 44v6 CR-C SCs and reduced metastatic growth.
Journal ArticleDOI
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
Milena Schiraldi,Angela Raucci,Laura Martínez Muñoz,Elsa Livoti,Barbara Celona,Emilie Venereau,Tiziana Apuzzo,Francesco De Marchis,Mattia Pedotti,Angela Bachi,Marcus Thelen,Luca Varani,Mario Mellado,Amanda E. I. Proudfoot,Marco Bianchi,Mariagrazia Uguccioni +15 more
TL;DR: CXCL12 forms a complex with HMGB1 that binds to the chemokine receptor CXCR4 and increases inflammatory cell migration and increasesinflammatory cell migration.
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Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer.
Ann Zeuner,Federica Francescangeli,Paola Contavalli,G Zapparelli,Tiziana Apuzzo,Adriana Eramo,Marta Baiocchi,M L De Angelis,Mauro Biffoni,Giovanni Sette,Matilde Todaro,Giorgio Stassi,R De Maria +12 more
TL;DR: ABT-737 as a single agent was able to inhibit the growth of LCSC-derived xenografts and to reduce cancer stem cell content in treated tumors, indicating Bcl-XL inhibition as a potential therapeutic avenue in NSCLC.
Journal ArticleDOI
CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
TL;DR: Observations indicate that during chemotaxis CCR2 acts as scavenger consuming the chemokine forming the attracting cue, and cycles rapidly back to the plasma membrane to maintain high responsiveness after relocation of the source of attractant.
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CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice.
Patrick Brennecke,Matthias J.E. Arlt,Carmen Campanile,Knut Husmann,Ana Gvozdenovic,Tiziana Apuzzo,Marcus Thelen,Walter Born,Bruno Fuchs +8 more
TL;DR: In this paper, the CXCR4-blocking principle was investigated for the first time in a spontaneously metastasizing human 143B osteosarcoma (OS) cell line-derived orthotopic xenograft mouse model.