Simon E. Ward

TL;DR: An in-depth analysis of the function, role and therapeutic potential of 450 expert-curated human DDR genes is presented, and systematic computational analysis is applied to identify DDR proteins that are amenable to modulation by small molecules, highlighting potential novel therapeutic targets.

TL;DR: The synthesis of polyprenylated phloroglucinol natural products, including clusianone, nemorosone, and garsubellin A, was pursued by a strategy involving construction of a core bicyclo nonanetrione structure and subsequent elaboration via organolithium intermediates.

TL;DR: The challenges involved in identifying a chemically distinct series of AMPA receptor positive modulators are outlined, addressing the challenges created by the heterogeneity of the AMPA receptors populations and the development of structure‐activity relationships driven by homomeric, recombinant systems on high‐throughput platforms are addressed.

TL;DR: In this article, the authors describe the rationale behind a new proposed measurement of the screening effect of an equipment enclosure that takes into account the contents of the enclosure, using a set of representative contents for enclosures.

TL;DR: TDP1 is established as a potential therapeutic target for the treatment of colorectal cancer and the validity of TOP1 or TDP1 on their own as predictive biomarkers for irinotecan response is questioned.