S
Simon Monard
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 31
Citations - 4076
Simon Monard is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 18, co-authored 29 publications receiving 3966 citations. Previous affiliations of Simon Monard include Los Alamos National Laboratory & Lincoln's Inn.
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Journal ArticleDOI
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Graham S. Ogg,Xia Jin,Sebastian Bonhoeffer,P R Dunbar,Martin A. Nowak,Simon Monard,Jeremy P. Segal,Yunzhen Cao,Sarah Rowland-Jones,Vincenzo Cerundolo,Arlene Hurley,M. Markowitz,David D. Ho,Douglas F. Nixon,Andrew J. McMichael +14 more
TL;DR: With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load and suggest a considerable cytopathic effect of the virus in vivo.
Journal ArticleDOI
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
Santiago Partida-Sanchez,Debra A. Cockayne,Simon Monard,Elaine L. Jacobson,Norman J. Oppenheimer,Beth A. Garvy,Kim Kusser,Stephen Goodrich,Maureen Howard,Allen G. Harmsen,Troy D. Randall,Frances E. Lund +11 more
TL;DR: It is demonstrated that neutrophil chemotaxis to bacterial chemoattractants is dependent on Ca++ mobilization mediated by cyclic ADP-ribose, and CD38 acts as a critical regulator of inflammation and innate immune responses.
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Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques
Hiroshi Mohri,Sebastian Bonhoeffer,Sebastian Bonhoeffer,Simon Monard,Simon Monard,Alan S. Perelson,Alan S. Perelson,David D. Ho,David D. Ho +8 more
TL;DR: Quantitative analyses of the sequential changes in bromodeoxyuridine labeling of CD4 and CD8 T lymphocytes revealed normal proliferation and death rates in uninfected macaques, but showed a substantial increase in these rates associated with simian immunodeficiency virus (SIV) infection.
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Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy
Graham S. Ogg,Xia Jin,Sebastian Bonhoeffer,Paul Moss,Martin A. Nowak,Simon Monard,Jeremy P. Segal,Yunzhen Cao,Sarah Rowland-Jones,Arlene Hurley,M. Markowitz,David D. Ho,Andrew J. McMichael,Douglas F. Nixon +13 more
TL;DR: Using HLA/peptide tetrameric complexes, it is shown that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks, followed by an exponential decay which continues while viremia remains undetectable.
Journal ArticleDOI
Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.
TL;DR: For the first time, the presence of endogenous HCMV within bone marrow progenitors in the absence of H CMV lytic gene expression is demonstrated, consistent with previous evidence showing that the permissiveness of myeloid cells for HCMVs is critically dependent on the differentiation state of the cell.