S
Simon Young
Researcher at University of Texas Health Science Center at Houston
Publications - 67
Citations - 4203
Simon Young is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Bone regeneration & Medicine. The author has an hindex of 23, co-authored 57 publications receiving 3486 citations. Previous affiliations of Simon Young include University of Texas System & Harvard University.
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Gelatin as a delivery vehicle for the controlled release of bioactive molecules.
TL;DR: This review will emphasize how biomolecules released from gelatin controlled-release systems are able to retain their biological activity, allowing for their use in tissue engineering, therapeutic angiogenesis, gene therapy, and drug delivery applications.
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Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model
TL;DR: The results indicate that delivery of both growth factors may enhance bone bridging and union of the critical size defect compared to delivery of BMP-2 alone and suggests an interplay between these growth factors for early bone regeneration.
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Evaluation of bone regeneration using the rat critical size calvarial defect.
Patrick P. Spicer,James D. Kretlow,James D. Kretlow,Simon Young,Simon Young,John A. Jansen,F. Kurtis Kasper,Antonios G. Mikos +7 more
TL;DR: The protocol for one such model, the rat calvarial defect, is described, which allows for evaluation of biomaterials and bone tissue engineering approaches within a reproducible, non-load-bearing orthotopic site.
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Injectable biomaterials for regenerating complex craniofacial tissues.
TL;DR: In this review, injectable materials that form scaffolds or networks capable of both replacing tissue function early after delivery and supporting tissue regeneration over a time period of weeks to months are examined.
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Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model
Simon Young,Zarana S. Patel,James D. Kretlow,Matthew B. Murphy,Paschalia M. Mountziaris,L. Scott Baggett,Hiroki Ueda,Yasuhiko Tabata,John A. Jansen,Mark E. Wong,Antonios G. Mikos +10 more
TL;DR: The dose effect of dual delivery of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) on bone regeneration was investigated in a rat cranial critical-size defect and the addition of VEGF was unable to reverse this decrease in PBF, although improvements in the number of bridged defects did occur in some groups.