S
Simona Volpi
Researcher at National Institutes of Health
Publications - 33
Citations - 14954
Simona Volpi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Regulation of gene expression & Translation (biology). The author has an hindex of 19, co-authored 29 publications receiving 10987 citations.
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Journal ArticleDOI
Anti-apoptotic actions of vasopressin in h32 neurons involve map kinase transactivation and bad phosphorylation
TL;DR: The data suggest that VP has anti-apoptotic activity in neurons and that VP may act as a neuroprotective agent in the brain.
Journal ArticleDOI
Inhibition of Vasopressin V1b Receptor Translation By Upstream Open Reading Frames in the 5′-Untranslated Region
TL;DR: It is suggested that translation of a 38‐amino acid membrane peptide encoded by uORF1 exerts tonic inhibition of V1bR translation.
Journal ArticleDOI
Translational regulation of the vasopressin v1b receptor involves an internal ribosome entry site.
TL;DR: Regulation of IRES activity in the 5'UTR of the V1bR mRNA probably through phosphorylation of eIF4G may serve as a mechanism for rapid changes in V 1bR translation to meet physiological demands.
Journal ArticleDOI
Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.
Geoffrey S. Ginsburg,Larisa H. Cavallari,Hrishikesh Chakraborty,Rhonda M. Cooper-DeHoff,Paul R. Dexter,Michael T. Eadon,Bart S. Ferket,Carol R. Horowitz,Julie A. Johnson,Joseph L. Kannry,Natalie Kucher,Ebony B. Madden,Lori A. Orlando,Wanda Parker,Josh F. Peterson,Victoria M. Pratt,Tejinder K Rakhra-Burris,Michelle A Ramos,Todd C. Skaar,Nina R. Sperber,Kady-Ann Steen-Burrell,Sara L. Van Driest,Deepak Voora,Kristin Wiisanen,Almut G. Winterstein,Simona Volpi,Ignite Ptn +26 more
TL;DR: IGNITE PTN as mentioned in this paper is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions.
Journal ArticleDOI
Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway.
TL;DR: The data support the hypothesis that VP contributes to pituitary V1bR upregulation during stress through GAGA binding-mediated transcriptional activation through transactivation of the EGFR and MAP kinase.