M
Michael T. Eadon
Researcher at Indiana University
Publications - 83
Citations - 1572
Michael T. Eadon is an academic researcher from Indiana University. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 17, co-authored 69 publications receiving 987 citations. Previous affiliations of Michael T. Eadon include Indiana University – Purdue University Indianapolis & Rush University Medical Center.
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Journal ArticleDOI
TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.
TL;DR: The findings confirm the important role of glomerular endothelial injury, possibly by a decreased VEGF level, in the development and progression of AKI and albuminuria in the LPS model of sepsis in the mouse.
Journal ArticleDOI
International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms
Kathleen M. Giacomini,Praveen Balimane,Sung Kweon Cho,Michael T. Eadon,Timi Edeki,Kathleen M. Hillgren,Huang Sm,Y. Sugiyama,Dietmar Weitz,Yujia Wen,Cindy Q. Xia,Sook Wah Yee,H. Zimdahl,Mikko Niemi +13 more
TL;DR: The clinical evidence demonstrating the role of transporter polymorphisms in variation in pharmacokinetics and pharmacodynamics is described, along with their allele frequencies in ethnic populations.
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Rationale and design of the Kidney Precision Medicine Project
Ian H. de Boer,Charles E. Alpers,Evren U. Azeloglu,Ulysses G. Balis,Jonathan Barasch,Laura Barisoni,Kristina N. Blank,Andrew S. Bomback,Keith Brown,Pierre C. Dagher,Ashveena Dighe,Michael T. Eadon,Tarek M. El-Achkar,Joseph P. Gaut,Nir Hacohen,Yongqun He,J. Hodgin,Sanjay Jain,John A. Kellum,Krzysztof Kiryluk,Richard J. Knight,Zoltan G. Laszik,Chrysta Lienczewski,Laura H. Mariani,Robyn L. McClelland,Steven Menez,Dennis G. Moledina,Sean D. Mooney,John F. O’Toole,Paul M. Palevsky,Paul M. Palevsky,Chirag R. Parikh,Emilio D. Poggio,Sylvia E. Rosas,Matthew R. Rosengart,Minnie M. Sarwal,Jennifer A. Schaub,John R. Sedor,Kumar Sharma,Becky Steck,Robert D. Toto,Olga G. Troyanskaya,Katherine Tuttle,Miguel A. Vazquez,Sushrut S. Waikar,Kayleen Williams,Francis P. Wilson,Kun Zhang,Ravi Iyengar,Matthias Kretzler,Jonathan Himmelfarb,Stewart H. Lecker,Isaac E. Stillman,Sushrut Waikar,Gearoid M. McMahon,Astrid Weins,Samuel Short,Paul Hoover,Mark Aulisio,Leslie Cooperman,Leal Herlitz,John F. O'Toole,Emilio Poggio,John Sedor,Stacey E. Jolly,Paul S. Appelbaum,Olivia Balderes,Jonathan Barasch,Andrew S. Bomback,Pietro A. Canetta,Vivette D. D'Agati,Satoru Kudose,Karla Mehl,Jai Radhakrishnan,Chenhua Weng,Theodore Alexandrov,Tarek Ashkar,Daria Barwinska,Pierre Dagher,Kenneth W. Dunn,Michael Eadon,Michael J. Ferkowicz,Katherine J. Kelly,Timothy A. Sutton,Seth Winfree,Chirag Parikh,Avi Z. Rosenberg,Pam Villalobos,Rubab Malik,Derek M. Fine,Mohammed Atta,Jose Manuel Monroy Trujillo,Alison Slack,Sylvia Rosas,Mark E. Williams,Evren Azeloglu,Cijang (John) He,Jens Hansen,Samir M. Parikh,Brad H. Rovin,Christopher R. Anderton,Ljiljana Paša-Tolić,Dušan Veličković,Jessica K Lukowski,George (Holt) Oliver,Joseph Ardayfio,Jack Bebiak,Taneisha Campbell,Catherine Campbell,Lynda Hayashi,Nichole Jefferson,Robert Koewler,Glenda V. Roberts,John Saul,Anna Shpigel,Edith Christine Stutzke,Lorenda Wright,Leslie Miegs,Roy Pinkeney,Rachel Sealfon,Olga G. Troyanskaya,Katherine R. Tuttle,Dejan Dobi,Yury Goltsev,Maria Joanes,Zoltan Laszik,Andrew Schroeder,Minnie M. Sarwal,Tara K. Sigdel,Ulysses J. Balis,Victoria Blanc,Oliver He,Jeffrey B. Hodgin,Laura H. Mariani,Rajasree Menon,Edgar A. Otto,Jennifer A. Schaub,Sean Eddy,Michele Elder,Daniel Hall,John A. Kellum,Mary Kruth,Raghav Murugan,Paul M. Palevsky,Parmjeet Randhawa,Matthew R. Rosengart,Sunny Sims-Lucas,Mary Stefanick,Stacy Stull,Mitchell Tublin,Charles E. Alpers,Ian de Boer,Ashveena Dighe,Robyn L. McClelland,Sean D. Mooney,Stuart J. Shankland,Kristina N. Blank,Jonas M Carson,Frederick Dowd,Zach Drager,Christopher Y. Park,Guanshi Zhang,Shweta Bansal,Manjeri A. Venkatachalam,Asra Kermani,Simon Lee,Christopher Y. Lu,Tyler Miller,Orson W. Moe,Harold Park,Kamalanathan K. Sambandam,Francisco Sanchez,Jose R. Torrealba,Toto Robert,Miguel A. Vazquez,Nancy Wang,Joe Gaut,Anitha Vijayan,Randy L. Luciano,Dennis G. Moledina,Ugwuowo Ugochukwu,Sandy Alfano +181 more
TL;DR: The Kidney Precision Medicine Project (KMP) as discussed by the authors aims to ethically and safely obtain kidney biopsies from participants with chronic kidney disease (CKD) or acute kidney injury (AKI) and create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes.
Journal ArticleDOI
Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells.
Seth Winfree,Shehnaz Khan,Radmila Micanovic,Michael T. Eadon,Katherine J. Kelly,Timothy A. Sutton,Carrie L. Phillips,Kenneth W. Dunn,Tarek M. El-Achkar +8 more
TL;DR: Volumetric Tissue Exploration and Analysis (VTEA) as mentioned in this paper is a 3D image analysis software designed for efficient exploration and quantitative analysis of large, complex 3D microscopy datasets.
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Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion.
Samvel R. Mkrtchyan,Ruben M. Markosyan,Michael T. Eadon,John P. Moore,Gregory B. Melikyan,Fredric S. Cohen +5 more
TL;DR: As the time of cell coincubation at 23°C was prolonged, more cells quickly fused upon the raising of the temperature to 37°C, and the increase quantitatively correlated with the greater percentage of fusion that was resistant to drugs, therefore the pronounced kinetic delay in HIV Env-induced fusion is caused predominantly by the time needed for ternary complexes to form.