D
Douglas S. Darling
Researcher at University of Louisville
Publications - 87
Citations - 7373
Douglas S. Darling is an academic researcher from University of Louisville. The author has contributed to research in topics: Thyroid hormone receptor & Receptor. The author has an hindex of 41, co-authored 87 publications receiving 6876 citations. Previous affiliations of Douglas S. Darling include University of Chicago & Brigham and Women's Hospital.
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Journal ArticleDOI
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
Journal ArticleDOI
Identification of a thyroid hormone receptor that is pituitary-specific.
Richard A. Hodin,Mitchell A. Lazar,BI Wintman,Douglas S. Darling,R J Koenig,P. R. Larsen,David D. Moore,William W. Chin +7 more
TL;DR: The presence of a pituitary-specific form of the thyroid hormone receptor that may be selectively regulated by thyroid hormone could be important for the differential regulation of gene expression by T3 in the pituitsary gland.
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EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.
Ester Sánchez-Tilló,Yongqing Liu,Oriol de Barrios,Laura Siles,Lucia Fanlo,Miriam Cuatrecasas,Douglas S. Darling,Douglas C. Dean,Antoni Castells,Antonio Postigo +9 more
TL;DR: EMT-ATFs have been shown to cooperate in oncogenic transformation, regulate cancer cell stemness, override safeguard programs against cancer like apoptosis and senescence, determine resistance to chemotherapy and promote tumor angiogenesis.
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A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
TL;DR: A cDNA encoding a novel member of the thyroid/steroid hormone receptor superfamily, called Rev-ErbA alpha, has been isolated from a rat GH3 cell library and described, finding that this DNA fragment also contained a portion of the c-erbA alpha gene.
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ZEB1 Links Epithelial-Mesenchymal Transition and Cellular Senescence
TL;DR: Zeb1 dosage-dependent deregulation of epithelial and mesenchymal genes extends to mouse embryonic fibroblasts (MEFs), and mutant MEFs also display diminished replicative capacity in culture, leading to premature senescence.