Journal ArticleDOI
Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling
Mónica P. A. Ferreira,Sanjeev Ranjan,Sini Kinnunen,Alexandra Correia,Virpi Talman,Ermei Mäkilä,Ermei Mäkilä,Brianda Barrios-Lopez,Marianna Kemell,Vimalkumar Balasubramanian,Jarno Salonen,Jouni Hirvonen,Heikki Ruskoaho,Anu J. Airaksinen,Hélder A. Santos +14 more
TLDR
In vivo single-photon emission computed tomography and autoradiography demonstrate increased accumulation of ANP-PSi nanoparticles in the ischemic heart, particularly in the endocardial layer of the left ventricle, demonstrating cardioprotective potential.Abstract:
Ischemic heart disease is the leading cause of death globally. Severe myocardial ischemia results in a massive loss of myocytes and acute myocardial infarction, the endocardium being the most vulnerable region. At present, current therapeutic lines only ameliorate modestly the quality of life of these patients. Here, an engineered nanocarrier is reported for targeted drug delivery into the endocardial layer of the left ventricle for cardiac repair. Biodegradable porous silicon (PSi) nanoparticles are functionalized with atrial natriuretic peptide (ANP), which is known to be expressed predominantly in the endocardium of the failing heart. The ANP-PSi nanoparticles exhibit improved colloidal stability and enhanced cellular interactions with cardiomyocytes and non-myocytes with minimal toxicity. After confirmation of good retention of the radioisotope 111-Indium in relevant physiological buffers over 4 h, in vivo single-photon emission computed tomography (SPECT/CT) imaging and autoradiography demonstrate increased accumulation of ANP-PSi nanoparticles in the ischemic heart, particularly in the endocardial layer of the left ventricle. Moreover, ANP-PSi nanoparticles loaded with a novel cardioprotective small molecule attenuate hypertrophic signaling in the endocardium, demonstrating cardioprotective potential. These results provide unique insights into the development of nanotherapies targeted to the injured region of the myocardium.read more
Citations
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Nanoparticles for targeting the infarcted heart
Tal Dvir,Michael Bauer,Avi Schroeder,Jonathan H. Tsui,Daniel G. Anderson,Robert Langer,Ronglih Liao,Daniel S. Kohane +7 more
TL;DR: A nanoparticulate system capable of targeting the heart after myocardial infarction based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart is reported.
Journal ArticleDOI
Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration.
Virpi Talman,Riikka Kivelä +1 more
TL;DR: The known mediators of the bidirectional CM-EC interactions are summarized and related recent advances in the development of therapies aiming to promote heart repair and regeneration targeting these two cell types are discussed.
Journal ArticleDOI
Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications
Terence Tieu,Terence Tieu,María D. Alba,María D. Alba,Roey Elnathan,Anna Cifuentes-Rius,Nicolas H. Voelcker,Nicolas H. Voelcker,Nicolas H. Voelcker +8 more
TL;DR: In this article, a review of porous silicon (pSi)-based nanomaterials including nanoparticles, nanowires, and thin films is presented, with a focus on their effective use in future clinical settings.
Journal ArticleDOI
Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats
Chang-xiong Zhang,Ying Cheng,Dao-zhou Liu,Miao Liu,Han Cui,Bang-Le Zhang,Qibing Mei,Si-Yuan Zhou +7 more
TL;DR: Mitochondria-targeted nanoparticles (CsA@PLGA-PEG-SS31) exhibited significant cardioprotective effects against MI/RI in rats hearts through protecting mitochondrial integrity, decreasing apoptosis of cardiomyocytes and myocardial infract area and offered a promising therapeutic method for patients with acute myocardIAL infarction.
Journal ArticleDOI
Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction.
Paul-Mihai Boarescu,Ioana Chirila,Adriana Elena Bulboacă,Ioana Corina Bocșan,Raluca Maria Pop,Dan Gheban,Sorana D. Bolboacă +6 more
TL;DR: CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels after MI and better prevented myocardial necrosis and reduced interstitial edema and neutrophil infiltration than CC, on histopathological examination.
References
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Journal ArticleDOI
Principles of nanoparticle design for overcoming biological barriers to drug delivery
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Journal ArticleDOI
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Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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Journal ArticleDOI
Nanoparticle PEGylation for imaging and therapy
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Journal ArticleDOI
Left Ventricular Remodeling After Myocardial Infarction Pathophysiology and Therapy
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