P
Paul Hasler
Researcher at University of Basel
Publications - 51
Citations - 2757
Paul Hasler is an academic researcher from University of Basel. The author has contributed to research in topics: Neutrophil extracellular traps & Rheumatoid arthritis. The author has an hindex of 20, co-authored 48 publications receiving 2241 citations. Previous affiliations of Paul Hasler include University Hospital of Basel.
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Journal ArticleDOI
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
Anurag Gupta,Manjunath B. Joshi,Maria Philippova,Paul Erne,Paul Hasler,Sinuhe Hahn,Therese J. Resink +6 more
TL;DR: Findings offer new insight into mechanisms whereby NETs trigger damage to the endothelium in sepsis, small vessel vasculitis and possibly the villous trophoblast in preeclampsia.
Journal ArticleDOI
Induction of Neutrophil Extracellular DNA Lattices by Placental Microparticles and IL-8 and Their Presence in Preeclampsia
TL;DR: Large numbers of NETs were present directly in the intervillous space of preeclamptic placentae, and their increased presence in preeclampsia suggests that NETs may play a role in the underlying pathology.
Journal ArticleDOI
Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group
Jérôme Avouac,Jaap Fransen,Ulrich A. Walker,Valeria Riccieri,Vanessa Smith,Carolina de Souza Müller,I. Miniati,Ingo H. Tarner,S. Bellando Randone,Maurizio Cutolo,Yannick Allanore,Oliver Distler,Gabriele Valentini,L. Czirják,Ulf Müller-Ladner,Daniel E. Furst,A Tyndall,Marco Matucci-Cerinic,F De Keyser,Alberto Sulli,Carmen Pizzorni,Britta Maurer,Stanislaw Sierakowsky,Otylia Kowal-Bielecka,P. Coelho,G. Riemekasten,Simona Rednic,Ileana Nicoara,Roberto Caporali,Jiri Stork,Murat Inanc,Patricia Carreira,Srdan Novak,Cecília Varjú,Carlo Chizzolini,Camillo Ribi,Eugeniusz J. Kucharz,AT Kotulska,Małgorzata Widuchowska,Jutta G Richter,A. Sipek-Dolnicar,Blaž Rozman,Armando Gabrielli,Gianluca Moroncini,Dominique Farge,C. Durant,Hans P. Kiener,E. Rath,Paolo Airò,Frank A. Wollheim,Nicolas Hunzelmann,Stefano Bombardieri,A. Della Rossa,Laura Bazzichi,Raffaele Pellerito,M. Saracco,Christopher P. Denton,Madelon C. Vonk,F.H.J. van den Hoogen,Nemanja Damjanov,Ina Kötter,Stefan Heitmann,Matthias Seidel,Paul Hasler,J.M. van Laar,Maria João Salvador,J.A. Pereira da Silva,Søren Jacobsen,Margitta Worm,Annegret Kuhn,Tatiana Nevskaya,Evgeny Nasonov,Raffaella Scorza,Henrik Nielsen,Richard M. Silver,Eric Hachulla,D. Launay,Guido Valesini,Ruxandra Ionescu,Daniela Opris,N. Del Papa,Wanda Maglione,D. Comina,G. Udrea,Coziana Ciurtin,R. Ionitescu,C. Mihai,Cord Sunderkötter,Jae Bum Jun,Chris T. Derk,S. Alhasani,L. Alhajjar,Evelien Ton,James R. Seibold,Peter Nash,Luc Mouthon,C. A. Von Mühlen,Brigitte Krummel-Lorenz,P. Eilbacher,Rene Westhovens,E. De Langhe,Miroslav Mayer,Branimir Anić,M. Baresic,F. Stoeckl,Maria Uprus,S. Popa,M. Buslau,B. Granel,Thierry Zenone,Alessandro Mathieu,Alessandra Vacca,Paolo Amerio,T. Tourinho,L. Lonzetti,M. Lemos Lopes,R. E. de Souza,D. Vealex,Paola Caramaschi,Alexandra Balbir-Gurman,Y. Braun,Susanne Ullman,Magdalena Szmyrka-Kaczmarek,Ewa Morgiel,Marie Vanthuyne,M. Meurer,P. Rehberger,Percival D. Sampaio-Barros +127 more
TL;DR: A core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis were identified in a Delphi exercise among 110 experts in the field of SSc.
Journal ArticleDOI
Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility
Chanchal Sur Chowdhury,Stavros Giaglis,Ulrich A. Walker,Andreas Buser,Sinuhe Hahn,Paul Hasler +5 more
TL;DR: Signaling elements associated with the extrusion of NETs are significantly enhanced to promote NETosis in RA compared with healthy controls, and the quantitation of NETosis-derived products may be a useful complementary tool to discriminate between healthy controls and RA cases.
Journal ArticleDOI
Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A
TL;DR: The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically supress or modulate NETosis and provide new insight into the mechanism whereby such immune suppressive drugs render transplant patients susceptible to opportunistic fungal infections.