S
Siôn R. Phillips
Researcher at University of Newcastle
Publications - 16
Citations - 901
Siôn R. Phillips is an academic researcher from University of Newcastle. The author has contributed to research in topics: Melanocortin 1 receptor & Extracellular matrix. The author has an hindex of 10, co-authored 14 publications receiving 868 citations. Previous affiliations of Siôn R. Phillips include Newcastle University.
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Journal ArticleDOI
Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair.
Helgi B. Schiöth,Siôn R. Phillips,Richard Rudzish,Mark A. Birch-Machin,Jarl E. S. Wikberg,Jonathan L. Rees +5 more
TL;DR: Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair as discussed by the authors, which is associated with the red hair mutation in humans.
Journal ArticleDOI
A Novel Zinc-regulated Human Zinc Transporter, hZTL1, Is Localized to the Enterocyte Apical Membrane
Ruth A. Cragg,Graham R. Christie,Siôn R. Phillips,Rachel M. Russi,Sébastien Küry,John C. Mathers,Peter M. Taylor,Dianne Ford +7 more
TL;DR: The localization, regulatory properties, and function of hZTL1 indicate a role in regulating the absorption of dietary zinc across the apical enterocyte membrane.
Journal ArticleDOI
Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation
RA Cragg,Siôn R. Phillips,J M Piper,J. S. Varma,Frederick Charles Campbell,John C. Mathers,Dianne Ford +6 more
TL;DR: Observations indicate that, in response to variations in dietary zinc intakes, regulated expression of plasma membrane zinc transporters in the human intestine contributes to maintenance of zinc status.
Journal ArticleDOI
Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair
Aneta Ringholm,Janis Klovins,Janis Klovins,Richard Rudzish,Siôn R. Phillips,Jonathan L. Rees,Helgi B. Schiöth +6 more
TL;DR: The results provide important pharmacological characterization of common MC1 receptor variants in various world populations and their ability to bind alpha-melanocyte stimulating hormone (MSH) peptides and increase intracellular cAMP.
Journal ArticleDOI
Enhanced cell attachment using a novel cell culture surface presenting functional domains from extracellular matrix proteins.
Michael J. Cooke,Siôn R. Phillips,Deepan S. H. Shah,Dale Athey,Jeremy H. Lakey,Stefan Przyborski +5 more
TL;DR: Surfaces coated with motifs from collagen I, collagen IV, fibronectin and laminin can mimic surfaces coated with the corresponding whole molecules and it is shown that the adherence of cells can be controlled by modifying the hydropathic properties of the surface to either enhance or inhibit cell attachment.