Sjoerd J Klaasen

TL;DR: It is concluded that ongoing CIN is common in colorectal cancer organoids, and proposed that CIN levels and the tolerance for mitotic errors shape aneuploidy landscapes and karyotype heterogeneity.

TL;DR: The authors found that chromosomes have different segregation error frequencies that result in non-random aneuploidy landscapes and that mis-segregating chromosomes frequently also preferentially become entrapped in micronuclei.

TL;DR: The authors found that chromosomes have different segregation error frequencies that result in non-random aneuploidy landscapes and that mis-segregating chromosomes frequently also preferentially become entrapped in micronuclei.

TL;DR: In this article , the authors show that the fibrous corona is essential for the nucleation of kinetochore-derived microtubules, and when dissociated from the core kenochore, it retains microtubule nucleation capacity.

TL;DR: In this article , the authors reviewed recent progress in understanding the prevalence and causes of non-random chromosome segregation errors in mammalian mitosis and meiosis, and evaluated its potential impact on cancer and human reproduction and discuss possible research avenues.