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Ana C.F. Bolhaqueiro
Researcher at University Medical Center Utrecht
Publications - 5
Citations - 244
Ana C.F. Bolhaqueiro is an academic researcher from University Medical Center Utrecht. The author has contributed to research in topics: Cancer & Chromosome instability. The author has an hindex of 4, co-authored 4 publications receiving 137 citations. Previous affiliations of Ana C.F. Bolhaqueiro include American Academy of Arts and Sciences & Royal Netherlands Academy of Arts and Sciences.
Papers
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Journal ArticleDOI
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.
Ana C.F. Bolhaqueiro,Bas Ponsioen,Bjorn Bakker,Sjoerd J Klaasen,Emre Kucukkose,Richard H. van Jaarsveld,Judith Vivié,Ingrid Verlaan-Klink,Nizar Hami,Diana C.J. Spierings,Nobuo Sasaki,Devanjali Dutta,Sylvia F. Boj,Robert G.J. Vries,Peter M. Lansdorp,Peter M. Lansdorp,Marc van de Wetering,Alexander van Oudenaarden,Hans Clevers,Onno Kranenburg,Floris Foijer,Hugo J. Snippert,Geert J. P. L. Kops +22 more
TL;DR: It is concluded that ongoing CIN is common in colorectal cancer organoids, and proposed that CIN levels and the tolerance for mitotic errors shape aneuploidy landscapes and karyotype heterogeneity.
Journal ArticleDOI
Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy
Inge Ubink,Ana C.F. Bolhaqueiro,Sjoerd G. Elias,Danielle A.E. Raats,Alexander Constantinides,N. A. Peters,Emma C. E. Wassenaar,I. H. J. T. de Hingh,Koen P. Rovers,W.M.U. Van Grevenstein,M. M. Laclé,G. J. P. L. Kops,I. H. M. Borel Rinkes,Onno Kranenburg +13 more
TL;DR: The aim of this study was to create a preclinical platform for the development of more effective intraperitoneal chemotherapy strategies.
Book ChapterDOI
Live imaging of cell division in 3D stem-cell organoid cultures.
Ana C.F. Bolhaqueiro,Richard H. van Jaarsveld,Bas Ponsioen,René M. Overmeer,Hugo J. Snippert,Geert J. P. L. Kops,Geert J. P. L. Kops +6 more
TL;DR: An approach for live imaging of cell division processes in intestinal organoid cultures derived from human and mouse adult stem cells is described, which can be extended to the analysis of cellular events in diseased tissue, such as patient-derived tumor organoids.
Journal ArticleDOI
A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation.
Timo E. F. Kuijt,Maaike L.A. Lambers,Sonja Weterings,Bas Ponsioen,Ana C.F. Bolhaqueiro,Debbie H.M. Staijen,Geert J. P. L. Kops +6 more
TL;DR: MPS1sen, a sensitive and specific FRET-based biosensor for MPS1 activity, is developed and shows deregulated Mps1 signaling dynamics in colorectal cancer cell lines and tumor organoids with diverse genomic instability phenotypes.
Posted ContentDOI
Predicting CIN rates from single-cell whole genome sequencing data using an in silico model
Bjorn Bakker,Michael Schubert,Ana C.F. Bolhaqueiro,Geert J. P. L. Kops,Diana C.J. Spierings,Floris Foijer +5 more
TL;DR: In this article , an in-silico model, called CINsim, was developed to simulate the karyotype dynamics and validated their model in a murine mouse model for T-cell lymphoma (T-ALL) in which CIN is introduced by mutation of the Mps1 spindle assembly checkpoint protein.