Solen Gokhan

TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.

TL;DR: This is the first report of long ncRNAs expression in neuronal and glial cell differentiation and of the modulation of ncRNA expression by modification of chromatin architecture.

TL;DR: Compared to wild type mice, CSF-1R-deficient mice have smaller brains of greater mass and ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brain size, an expanded Neural progenitor pool and elevated cellular apoptosis in cortical forebrain, indicating novel roles for the CSF/IL-34 receptor in the regulation of corticogenesis.

TL;DR: Observations suggest that developmental changes in neural progenitor cell responsiveness to the BMPs may represent a novel mechanism for orchestrating context-specific cellular events such as lineage elaboration and cellular viability.

TL;DR: The roles of the CSF-1R and its ligands in microglial and neural development and function, and their relevance to the understanding of neurodegenerative disease are reviewed.