L
Lai Guan Ng
Researcher at Agency for Science, Technology and Research
Publications - 143
Citations - 22962
Lai Guan Ng is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 56, co-authored 130 publications receiving 16292 citations. Previous affiliations of Lai Guan Ng include National University of Singapore & Institute of Molecular and Cell Biology.
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Journal ArticleDOI
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
Journal ArticleDOI
Dimensionality reduction for visualizing single-cell data using UMAP.
Etienne Becht,Leland McInnes,John Healy,Charles-Antoine Dutertre,Immanuel Kwok,Lai Guan Ng,Florent Ginhoux,Evan W. Newell,Evan W. Newell +8 more
TL;DR: Comparing the performance of UMAP with five other tools, it is found that UMAP provides the fastest run times, highest reproducibility and the most meaningful organization of cell clusters.
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The gut microbiota influences blood-brain barrier permeability in mice
Viorica Braniste,Maha Al-Asmakh,Czeslawa Kowal,Farhana Anuar,Afrouz Abbaspour,Miklós Tóth,Agata Korecka,Nadja Bakocevic,Lai Guan Ng,Parag Kundu,Balázs Gulyás,Balázs Gulyás,Christer Halldin,Christer Halldin,Kjell Hultenby,Harriet Nilsson,Hans Hebert,Bruce T. Volpe,Betty Diamond,Sven Pettersson,Sven Pettersson +20 more
TL;DR: It is shown that germ-free pregnant dams, devoid of maternal microbes, have offspring that show increased permeability of the blood-brain barrier, suggesting that crosstalk between the gut microbiota and the brain, initiated during the intrauterine period, is perpetuated throughout life.
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C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
Guillaume Hoeffel,Jinmiao Chen,Yonit Lavin,Donovan Low,Francisca F. Almeida,Peter See,Anna E. Beaudin,Josephine Lum,Ivy Low,E. Camilla Forsberg,Michael Poidinger,Francesca Zolezzi,Anis Larbi,Lai Guan Ng,Jerry Kok Yen Chan,Melanie Greter,Burkhard Becher,Igor M. Samokhvalov,Miriam Merad,Florent Ginhoux +19 more
TL;DR: It is shown that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs), which arise from erythro-myeloid progenitors (EMPs) generated in the YS.
Journal ArticleDOI
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
Andreas Schlitzer,Naomi McGovern,Pearline Teo,Teresa Zelante,Koji Atarashi,Donovan Low,Adrian W. S. Ho,Peter See,Amanda Shin,Pavandip Singh Wasan,Guillaume Hoeffel,Benoit Malleret,Alexander F. Heiseke,Samantha Chew,Laura Jardine,Harriet A. Purvis,Catharien M. U. Hilkens,John Kit Chung Tam,Michael Poidinger,E. Richard Stanley,Anne Krug,Laurent Rénia,Baalasubramanian Sivasankar,Lai Guan Ng,Matthew Collin,Paola Ricciardi-Castagnoli,Kenya Honda,Muzlifah Haniffa,Florent Ginhoux +28 more
TL;DR: The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies.