Song Kyu Park

TL;DR: It is shown that fission yeast has more essential genes than budding yeast and that essential genes are more likely than nonessential genes to be present in a single copy, to be broadly conserved and to contain introns.

TL;DR: An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment and exhibited significant antiprolifierative activity against human cultured cell lines.

TL;DR: The first report of PPARgamma activation by troglitazone (TG) exerting its inhibitory effects on LDL-induced cell proliferation via generation not of H(2)O(2), but of O2(.-), and the subsequent activation of Erk1/2 in hAoSMCs suggests that the regulation of O 2(.-) is located at the crossroads between LDL signaling and cell proliferation.

TL;DR: It is reported that LDL translocated PKCbeta(II) and PKCtheta from cytosol to plasma membrane, and inhibition of PKC beta(II), PKC theta, and GPCR decreased LDL effects via the deactivation of Erk1/2, suggesting that Gi protein plays a role in LDL effects.

TL;DR: This is the first report, to the authors' knowledge, that DIDS-sensitive Cl- channels play a key role in the LDL-induced cell proliferation of hAoSMCs via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1.