L
Lila Kim
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 11
Citations - 793
Lila Kim is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Schizosaccharomyces pombe & Downregulation and upregulation. The author has an hindex of 7, co-authored 9 publications receiving 702 citations. Previous affiliations of Lila Kim include Chungnam National University.
Papers
More filters
Journal ArticleDOI
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
Dong-Uk Kim,Jacqueline Hayles,Dongsup Kim,Valerie Wood,Valerie Wood,Han Oh Park,Misun Won,Hyang Sook Yoo,Trevor Duhig,Miyoung Nam,Georgia Palmer,Sangjo Han,Linda Jeffery,Seung Tae Baek,Hye-Mi Lee,Young Sam Shim,Minho Lee,Lila Kim,Kyung-Sun Heo,Eun Joo Noh,Ah Reum Lee,Young Joo Jang,Kyung Sook Chung,Shin Jung Choi,Jo Young Park,Young Woo Park,Hwan Mook Kim,Song Kyu Park,Hae Joon Park,Eun Jung Kang,Hyong Bai Kim,Hyun Sam Kang,Hee-Moon Park,Kyunghoon Kim,Kiwon Song,Kyung Bin Song,Paul Nurse,Paul Nurse,Kwang Lae Hoe +38 more
TL;DR: It is shown that fission yeast has more essential genes than budding yeast and that essential genes are more likely than nonessential genes to be present in a single copy, to be broadly conserved and to contain introns.
Journal ArticleDOI
The Fission Yeast GATA Factor, Gaf1, Modulates Sexual Development via Direct Down-Regulation of ste11+ Expression in Response to Nitrogen Starvation
TL;DR: Gaf1 provides the prime example for negative regulation of ste11+ transcription through direct binding to a cis-acting motif of its promoter, and binds to the canonical GATA motif spanning from −371 to −366 in Ste11+ promoter.
Journal ArticleDOI
PPARγ activation abolishes LDL-induced proliferation of human aortic smooth muscle cells via SOD-mediated down-regulation of superoxide
Kyung-Sun Heo,Kyung-Sun Heo,Dong-Uk Kim,Sungwoo Ryoo,Miyoung Nam,Seung Tae Baek,Lila Kim,Song Kyu Park,Chang-Seon Myung,Kwang Lae Hoe +9 more
TL;DR: The first report of PPARgamma activation by troglitazone (TG) exerting its inhibitory effects on LDL-induced cell proliferation via generation not of H(2)O(2), but of O2(.-), and the subsequent activation of Erk1/2 in hAoSMCs suggests that the regulation of O 2(.-) is located at the crossroads between LDL signaling and cell proliferation.
Journal ArticleDOI
PPARα activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells
Sung-Woo Ryoo,Sung-Woo Ryoo,Misun Won,Dong-Uk Kim,Lila Kim,Gyoonhee Han,Seung Kiel Park,Naofumi Mukaida,Pil-Jae Maeng,Hyang Sook Yoo,Kwang Lae Hoe +10 more
TL;DR: It is shown, for the first time, that the peroxisome proliferator-activated receptor (PPARα) agonist, fenofibrate, completely abolishes the LDL-induced IL-8 up-regulation at the transcriptional level.
Journal ArticleDOI
Activation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation
Kyung-Sun Heo,Dong-Uk Kim,Lila Kim,Miyoung Nam,Seung Tae Baek,Song Kyu Park,Young Woo Park,Chang-Seon Myung,Sung Ook Hwang,Kwang Lae Hoe +9 more
TL;DR: It is reported that LDL translocated PKCbeta(II) and PKCtheta from cytosol to plasma membrane, and inhibition of PKC beta(II), PKC theta, and GPCR decreased LDL effects via the deactivation of Erk1/2, suggesting that Gi protein plays a role in LDL effects.