Modified mycotoxins: An updated review on their formation, detection, occurrence, and toxic effects.

Biological functions of Trichoderma spp. for agriculture applications

Mycotoxin contamination and control strategy in human, domestic animal and poultry: A review.

Anopheles mosquitoes became one of the biggest problems threaten human life through causing malaria disease. Hereby, Selenium nanoparticles (Se-NPs) as anti-victor malaria were fabricated for the first time through Penicillium corylophilum in presence of ascorbic acid as a reducing agent. Antibacterial versus pathogenic Gram +Ve and Gram −Ve bacteria, as well, in vitro cytotoxicity against two types of cell lines (normal Wi 38 and cancer Caco-2) were explored prolonging with their larvicidal activity towards Anopheles stephensi mosquitoes. Se-NPs is characterized by UV–Vis spectroscopy, FT-IR, TEM, EDX, XRD, DLS. Results affirmed the ability of Penicillium corylophilum to build up Se-NPs in spherical shape with average size 29.1–48.9 nm. In addition, Se-NPs exhibited broad spectrum activity against pathogenic Gram +Ve and Gram −Ve bacteria, while the results obtained from cytotoxicity evaluation signified clearly that, alteration occurred in the cells was represented as loss of their typical shape, partial or complete loss of monolayer, granulation, shrinking or cell rounding with IC50 value of 171.8 and 104.3 ppm Wi 38 and Caco-2 cell lines respectively, which revealing the high toxicity of Se-NPs towards cancer cells compared with normal cells. However, Se-NPs displayed larvicidal activity against causative malaria vector Anopheles stephensi.

https://link.springer.com/content/pdf/10.1007/s10876-020-01794-8.pdf

Antibacterial, Cytotoxicity and Larvicidal Activity of Green Synthesized Selenium Nanoparticles Using Penicillium corylophilum

Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers.

Mycotoxin contamination is a significant health concern for human beings, but health risk assessments are usually based on one single mycotoxin, which might neglect the additive or competitive interactions between co-occurring mycotoxins [...].

https://www.mdpi.com/2072-6651/9/3/96/pdf

Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells.

Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins

Fumonisin contaminates food and feed extensively throughout the world, causing chronic and acute toxicity in human and animals. Currently, studies on the toxicology of fumonisins mainly focus on fumonisin B1 (FB1). Considering that FB1, fumonisin B2 (FB2) and fumonisin B3 (FB3) could coexist in food and feed, a study regarding a single toxin, FB1, may not completely reflect the toxicity of fumonisin. The gastrointestinal tract is usually exposed to these dietary toxins. In our study, the human gastric epithelial cell line (GES-1) was used as in vitro model to evaluate the toxicity of fumonisin. Firstly, we found that they could cause a decrease in cell viability, and increase in membrane leakage, cell death and the induction of expression of markers for endoplasmic reticulum (ER) stress. Their toxicity potency rank is FB1 > FB2 >> FB3. The results also showed that the synergistic effect appeared in the combinations of FB1 + FB2 and FB1 + FB3. Nevertheless, the combinations of FB2 + FB3 and FB1 + FB2 + FB3 showed a synergistic effect at low concentration and an antagonistic effect at high concentration. We also found that myriocin (ISP-1) could alleviate the cytotoxicity induced by fumonisin in GES-1 cells. Finally, this study may help to determine or optimize the legal limits and risk assessment method of mycotoxins in food and feed and provide a potential method to block the fumonisin toxicity.

https://www.mdpi.com/1422-0067/21/16/5917/pdf

Song Yu

Papers

Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells.

Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins

Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells.

Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells

Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signalling pathway in human esophageal epithelial cells.