Adnan Sali

TL;DR: The results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia, and interfere with TNAP activity may correct pathological hyperossification because of PPi insufficiency.

TL;DR: It is reported that extracellular PPi deficiency promotes osteopontin deficiency and correction of osteoponin deficiency prevents hypercalcification, suggesting synergistic inhibition of hydroxyapatite deposition.

TL;DR: Many developmentally regulated membrane proteins of lymphocytes are ecto‐enzymes, with their active sites on the external surface of the cell, commonly have peptidase, phosphodiesterase or nucleotidase activity and play a part in diverse activities in different tissues, including recycling of nucleotides.

TL;DR: Differential expression of PC-1 and B10 could modulate cartilage mineralization in degenerative joint diseases and appear to act principally in different intracellular compartments.

TL;DR: The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind as mentioned in this paper.